Changes in Activity of Matrix Metalloproteinases and Serum Concentrations of Proinsulin and C-Peptide Depending on the Compensation Stage of Type 2 Diabetes Mellitus
- Autores: Poteryaeva O.1, Russkikh G.1, Zubova A.1, Gevorgyan M.2, Usynin I.1
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Afiliações:
- Research Institute of Biochemistry
- Research Institute of Experimental and Clinical Medicine
- Edição: Volume 164, Nº 6 (2018)
- Páginas: 730-733
- Seção: Biophysics and Biochemistry
- URL: https://journals.rcsi.science/0007-4888/article/view/239883
- DOI: https://doi.org/10.1007/s10517-018-4068-z
- ID: 239883
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Resumo
In patients with type 2 diabetes mellitus, serum activities of MMP-2 and MMP-7 were substantially decreased in comparison with apparently healthy individuals. At the decompensation stage, along with the increased content of glucose and glycated hemoglobin, a pronounced (3-fold) increase in proinsulin concentration was observed. On the contrary, MMP activity and C-peptide concentration decreased at this stage. The ratio of proinsulin concentration to MMP activity at the stages of diabetes mellitus compensation and subcompensation was approximately 1:50, while at the stage of decompensation it was 1:12. Thus, the ratio of these blood serum parameters can be used as an additional diagnostic marker of diabetes decompensation and severity of its complications.
Sobre autores
O. Poteryaeva
Research Institute of Biochemistry
Autor responsável pela correspondência
Email: olga_poteryaeva@mail.ru
Rússia, Novosibirsk
G. Russkikh
Research Institute of Biochemistry
Email: olga_poteryaeva@mail.ru
Rússia, Novosibirsk
A. Zubova
Research Institute of Biochemistry
Email: olga_poteryaeva@mail.ru
Rússia, Novosibirsk
M. Gevorgyan
Research Institute of Experimental and Clinical Medicine
Email: olga_poteryaeva@mail.ru
Rússia, Novosibirsk
I. Usynin
Research Institute of Biochemistry
Email: olga_poteryaeva@mail.ru
Rússia, Novosibirsk