Changes in Activity of Matrix Metalloproteinases and Serum Concentrations of Proinsulin and C-Peptide Depending on the Compensation Stage of Type 2 Diabetes Mellitus
- Authors: Poteryaeva O.N.1, Russkikh G.S.1, Zubova A.V.1, Gevorgyan M.M.2, Usynin I.F.1
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Affiliations:
- Research Institute of Biochemistry
- Research Institute of Experimental and Clinical Medicine
- Issue: Vol 164, No 6 (2018)
- Pages: 730-733
- Section: Biophysics and Biochemistry
- URL: https://journals.rcsi.science/0007-4888/article/view/239883
- DOI: https://doi.org/10.1007/s10517-018-4068-z
- ID: 239883
Cite item
Abstract
In patients with type 2 diabetes mellitus, serum activities of MMP-2 and MMP-7 were substantially decreased in comparison with apparently healthy individuals. At the decompensation stage, along with the increased content of glucose and glycated hemoglobin, a pronounced (3-fold) increase in proinsulin concentration was observed. On the contrary, MMP activity and C-peptide concentration decreased at this stage. The ratio of proinsulin concentration to MMP activity at the stages of diabetes mellitus compensation and subcompensation was approximately 1:50, while at the stage of decompensation it was 1:12. Thus, the ratio of these blood serum parameters can be used as an additional diagnostic marker of diabetes decompensation and severity of its complications.
About the authors
O. N. Poteryaeva
Research Institute of Biochemistry
Author for correspondence.
Email: olga_poteryaeva@mail.ru
Russian Federation, Novosibirsk
G. S. Russkikh
Research Institute of Biochemistry
Email: olga_poteryaeva@mail.ru
Russian Federation, Novosibirsk
A. V. Zubova
Research Institute of Biochemistry
Email: olga_poteryaeva@mail.ru
Russian Federation, Novosibirsk
M. M. Gevorgyan
Research Institute of Experimental and Clinical Medicine
Email: olga_poteryaeva@mail.ru
Russian Federation, Novosibirsk
I. F. Usynin
Research Institute of Biochemistry
Email: olga_poteryaeva@mail.ru
Russian Federation, Novosibirsk