Email this article Comparative Analysis of Quantitative Parameters of Expression of the Retinoic Acid Nuclear Receptor RARα Gene and APE1/YB-1/MDR1 Pattern Genes in Patients with Newly Detected Multiple Myeloma
- Authors: Kalitin N.N.1, Chernykh Y.B.2, Buravtsova I.V.2
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Affiliations:
- N. N. Blokhin Russian Cancer Research Center, Ministry of Health of the Russian Federation
- M. F. Vladimirsky Moscow Regional Research and Clinical Institute
- Issue: Vol 164, No 1 (2017)
- Pages: 90-94
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/239384
- DOI: https://doi.org/10.1007/s10517-017-3931-7
- ID: 239384
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Abstract
The expression of retinoic acid nuclear receptor gene RARα and its relationship with expression of APE1, YB-1, and MDR1 genes was studied in bone marrow aspiration biopsy specimens from 22 patients with newly detected multiple myeloma. The expression of RARα directly correlated with the expression of APE1/YB-1/MDR1 pattern genes. Groups differing by expression of RARα exhibited significant differences in the overall survival of patients; concordant and simultaneous changes in the expression of all genes of the APE1/YB-1/MDR1 pattern suggested the level of RARα gene expression as a potential prognostic factor in the pathogenesis of multiple myeloma.
About the authors
N. N. Kalitin
N. N. Blokhin Russian Cancer Research Center, Ministry of Health of the Russian Federation
Author for correspondence.
Email: f.oskolov@mail.ru
Russian Federation, Moscow
Yu. B. Chernykh
M. F. Vladimirsky Moscow Regional Research and Clinical Institute
Email: f.oskolov@mail.ru
Russian Federation, Moscow
I. V. Buravtsova
M. F. Vladimirsky Moscow Regional Research and Clinical Institute
Email: f.oskolov@mail.ru
Russian Federation, Moscow
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