Dihydroquercetin Improves Microvascularization and Microcirculation in the Brain Cortex of SHR Rats during the Development of Arterial Hypertension
- Autores: Plotnikov M.1, Aliev O.1, Sidekhmenova A.1, Shamanaev A.1, Anishchenko A.1, Fomina T.1, Chernysheva G.1, Smol’yakova V.1, Arkhipov A.1
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Afiliações:
- Laboratory of Circulation Pharmacology, E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk Research Medical Center
- Edição: Volume 163, Nº 1 (2017)
- Páginas: 57-60
- Seção: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/238644
- DOI: https://doi.org/10.1007/s10517-017-3737-7
- ID: 238644
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Resumo
The effects of dihydroquercetin (50 mg/kg intragastrically daily for 6 weeks) on the density of capillary network (mean number of capillaries per mm2), mean capillary diameter, structure of capillary network, capillary diameter distribution (<3, 3-5, 5-7, and 7-9 μ), and local cerebral blood flow (by laser Doppler) in the visual cortex were studied in SHR rats during the development of arterial hypertension (from the 6th to the 12th week of life). Normally, the systolic and diastolic BP progressively increased in SHR rats during this period. Dihydroquercetin did not affect the development of arterial hypertension. At the same time, the drug significantly increased the mean diameter of capillaries (by 11%), capillary network density (by 23%), and in the percentage of capillaries with a diameter of 3-9 μ (passable for erythrocytes; by 42%). Positive effects of dihydroquercetin on the structure of microcirculatory bed improved microcirculation: local cerebral blood flow in the visual cortex of SHR rats was significantly higher (by 36%) than in rats receiving no flavonoid and close to the value in Wistar-Kyoto rats. Dihydroquercetin improved microvascularization and microcirculation in the cerebral cortex of SHR rats during the formation of arterial hypertension.
Sobre autores
M. Plotnikov
Laboratory of Circulation Pharmacology, E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk Research Medical Center
Autor responsável pela correspondência
Email: mbp2001@mail.ru
Rússia, Tomsk
O. Aliev
Laboratory of Circulation Pharmacology, E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk Research Medical Center
Email: mbp2001@mail.ru
Rússia, Tomsk
A. Sidekhmenova
Laboratory of Circulation Pharmacology, E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk Research Medical Center
Email: mbp2001@mail.ru
Rússia, Tomsk
A. Shamanaev
Laboratory of Circulation Pharmacology, E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk Research Medical Center
Email: mbp2001@mail.ru
Rússia, Tomsk
A. Anishchenko
Laboratory of Circulation Pharmacology, E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk Research Medical Center
Email: mbp2001@mail.ru
Rússia, Tomsk
T. Fomina
Laboratory of Circulation Pharmacology, E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk Research Medical Center
Email: mbp2001@mail.ru
Rússia, Tomsk
G. Chernysheva
Laboratory of Circulation Pharmacology, E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk Research Medical Center
Email: mbp2001@mail.ru
Rússia, Tomsk
V. Smol’yakova
Laboratory of Circulation Pharmacology, E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk Research Medical Center
Email: mbp2001@mail.ru
Rússia, Tomsk
A. Arkhipov
Laboratory of Circulation Pharmacology, E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk Research Medical Center
Email: mbp2001@mail.ru
Rússia, Tomsk