Sex-Related Characteristics of Systemic Hormonal Homeostasis in Rats with Sarcoma C-45 Cells Transplanted to the Lung
- Autores: Kozlova M.1, Frantsiyants E.1, Trepitaki L.1, Kaplieva I.1, Pogorelova Y.1, Sergostyants G.1, Airapetova T.1, Chubaryan A.1
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Afiliações:
- Rostov Research Institute of Oncology, Ministry of Health of the Russian Federation
- Edição: Volume 162, Nº 6 (2017)
- Páginas: 788-791
- Seção: Oncology
- URL: https://journals.rcsi.science/0007-4888/article/view/238570
- DOI: https://doi.org/10.1007/s10517-017-3714-1
- ID: 238570
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Resumo
Sex-related systemic status of pituitary and thyroid hormones and cortisol was studied in rats on days 7 and 14 after transplantation of sarcoma C-45 cells into the lung. Females demonstrated slower development of the tumor process (49.0±10.7 vs. 32.0±3.9 days in males). Injection of tumor cells causes similar disorders in the levels of ACTH, thyrotropic hormone, and prolactin in males and females and opposite disorders in the thyroid and glucocorticoid homeostasis associated in males (in contrast to females) with reduction of cortisol level (by 1.9 times) and increase in the concentrations of total thyroxine forms (by 1.4 times) and triiodothyronine (by 2.9 times) by day 14. Early sex-related shifts in the status of hormone that are a component of the adaptive system attest to their possible relationship with different course of the malignant process in male and female rats.
Sobre autores
M. Kozlova
Rostov Research Institute of Oncology, Ministry of Health of the Russian Federation
Autor responsável pela correspondência
Email: missis.marg-bor@yandex.ru
Rússia, Rostov-on-Don
E. Frantsiyants
Rostov Research Institute of Oncology, Ministry of Health of the Russian Federation
Email: missis.marg-bor@yandex.ru
Rússia, Rostov-on-Don
L. Trepitaki
Rostov Research Institute of Oncology, Ministry of Health of the Russian Federation
Email: missis.marg-bor@yandex.ru
Rússia, Rostov-on-Don
I. Kaplieva
Rostov Research Institute of Oncology, Ministry of Health of the Russian Federation
Email: missis.marg-bor@yandex.ru
Rússia, Rostov-on-Don
Yu. Pogorelova
Rostov Research Institute of Oncology, Ministry of Health of the Russian Federation
Email: missis.marg-bor@yandex.ru
Rússia, Rostov-on-Don
G. Sergostyants
Rostov Research Institute of Oncology, Ministry of Health of the Russian Federation
Email: missis.marg-bor@yandex.ru
Rússia, Rostov-on-Don
T. Airapetova
Rostov Research Institute of Oncology, Ministry of Health of the Russian Federation
Email: missis.marg-bor@yandex.ru
Rússia, Rostov-on-Don
A. Chubaryan
Rostov Research Institute of Oncology, Ministry of Health of the Russian Federation
Email: missis.marg-bor@yandex.ru
Rússia, Rostov-on-Don
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