Possible Role of Polymorphisms in TNFA, NFKB1, and CASP8 Gene Promoter Areas in the Development of Chronic Lymphocytic Leukemia
- Autores: Ovsepyan V.1, Shubenkina A.1, Zotova E.1
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Afiliações:
- Kirov Research Institute of Hematology and Blood Transfusion, Federal Medical-Biological Agency of Russia
- Edição: Volume 162, Nº 5 (2017)
- Páginas: 650-653
- Seção: Genetics
- URL: https://journals.rcsi.science/0007-4888/article/view/238432
- DOI: https://doi.org/10.1007/s10517-017-3679-0
- ID: 238432
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Resumo
We studied the relationship between polymorphisms rs1800629 (-308G>A), rs28362491 (-94ins>del), and rs3834129 (-652ins>del) in the promoter regions of TNFA, NFKB1, and CASP8 genes, respectively, encoding TNF-α, nuclear transcription factor κB1 (NF-κB1), and caspase 8 (CASP8), and the risk and stages of chronic lymphocytic leukemia in ethnic Russians, residents of the Vyatka region of Russia. Allele -308A, genotype -308AA, and -308A genotypes (-308AA/-308AG) were associated with the risk of this pathology (OR=1.64, 95%CI 1.14-2.37, p=0.007; OR=4.48, 95%CI 1.20-16.80, p=0.02, and OR=1.57, 95%CI 1.05-2.36, p=0.03). In addition, NFKB1 allele -94del and genotype -94del/del were associated with advanced stages of the disease at the time of diagnosis (OR=0.66, 95%CI 0.46-0.97, p=0.03 and OR=0.43, 95%CI 0.20-0.92, p=0.03). These data suggest that -308G>A and -94ins>del polymorphisms of genes TNFA and NFKB1, respectively, can be involved in the pathogenesis of chronic lymphocytic leukemia.
Sobre autores
V. Ovsepyan
Kirov Research Institute of Hematology and Blood Transfusion, Federal Medical-Biological Agency of Russia
Autor responsável pela correspondência
Email: vovsepyan@mail.ru
Rússia, Kirov
A. Shubenkina
Kirov Research Institute of Hematology and Blood Transfusion, Federal Medical-Biological Agency of Russia
Email: vovsepyan@mail.ru
Rússia, Kirov
E. Zotova
Kirov Research Institute of Hematology and Blood Transfusion, Federal Medical-Biological Agency of Russia
Email: vovsepyan@mail.ru
Rússia, Kirov