Structural and Functional State of Erythrocyte Membranes in Mice at Different Stages of Experimental Parkinson’s Disease Induced by Administration of 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP)
- Autores: Fatkullina L.1, Molochkina E.1, Kozachenko A.1, Nagler L.1, Burlakova E.1
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Afiliações:
- N. M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences
- Edição: Volume 162, Nº 5 (2017)
- Páginas: 597-601
- Seção: General Pathology and Pathophysiology
- URL: https://journals.rcsi.science/0007-4888/article/view/238399
- DOI: https://doi.org/10.1007/s10517-017-3666-5
- ID: 238399
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Resumo
We studied some structural and functional parameters of erythrocyte membranes in mice at the late presymptomatic and early symptomatic stages of experimental Parkinson’s disease induced by administration of MPTP (hemolysis, microviscosity of different regions of the lipid bilayer, LPO intensity, activity of antioxidant enzymes, and kinetic properties of acetylcholinesterase). At the presymptomatic stage, significant deviations of the studied parameters from the normal were observed; they were similar in direction and magnitude to those in humans with Parkinson’s disease. At the early symptomatic stage, most parameters tended to normal. Microviscosity of bulk lipids increased at the presymptomatic stage and decreased after appearance of clinical symptoms. This dynamics probably reflects activation of compensatory mechanisms aimed at inhibition of oxidative stress triggered by the development of the pathological process.
Sobre autores
L. Fatkullina
N. M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences
Autor responsável pela correspondência
Email: bcp_lfat@mail.ru
Rússia, Moscow
E. Molochkina
N. M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences
Email: bcp_lfat@mail.ru
Rússia, Moscow
A. Kozachenko
N. M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences
Email: bcp_lfat@mail.ru
Rússia, Moscow
L. Nagler
N. M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences
Email: bcp_lfat@mail.ru
Rússia, Moscow
E. Burlakova
N. M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences
Email: bcp_lfat@mail.ru
Rússia, Moscow