Structural and Functional State of Erythrocyte Membranes in Mice at Different Stages of Experimental Parkinson’s Disease Induced by Administration of 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP)
- Authors: Fatkullina L.D.1, Molochkina E.M.1, Kozachenko A.I.1, Nagler L.G.1, Burlakova E.B.1
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Affiliations:
- N. M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences
- Issue: Vol 162, No 5 (2017)
- Pages: 597-601
- Section: General Pathology and Pathophysiology
- URL: https://journals.rcsi.science/0007-4888/article/view/238399
- DOI: https://doi.org/10.1007/s10517-017-3666-5
- ID: 238399
Cite item
Abstract
We studied some structural and functional parameters of erythrocyte membranes in mice at the late presymptomatic and early symptomatic stages of experimental Parkinson’s disease induced by administration of MPTP (hemolysis, microviscosity of different regions of the lipid bilayer, LPO intensity, activity of antioxidant enzymes, and kinetic properties of acetylcholinesterase). At the presymptomatic stage, significant deviations of the studied parameters from the normal were observed; they were similar in direction and magnitude to those in humans with Parkinson’s disease. At the early symptomatic stage, most parameters tended to normal. Microviscosity of bulk lipids increased at the presymptomatic stage and decreased after appearance of clinical symptoms. This dynamics probably reflects activation of compensatory mechanisms aimed at inhibition of oxidative stress triggered by the development of the pathological process.
About the authors
L. D. Fatkullina
N. M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences
Author for correspondence.
Email: bcp_lfat@mail.ru
Russian Federation, Moscow
E. M. Molochkina
N. M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences
Email: bcp_lfat@mail.ru
Russian Federation, Moscow
A. I. Kozachenko
N. M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences
Email: bcp_lfat@mail.ru
Russian Federation, Moscow
L. G. Nagler
N. M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences
Email: bcp_lfat@mail.ru
Russian Federation, Moscow
E. B. Burlakova
N. M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences
Email: bcp_lfat@mail.ru
Russian Federation, Moscow