Inhibition of Apoptosis Stages of Human Blood Lymphocytes after Exposure to Carbon Monoxide in the Presence of Recombinant Interleukin-2
- Autores: Artyukhov V.1, Tyunina O.2
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Afiliações:
- Voronezh State University
- N. N. Burdenko Voronezh State Medical University
- Edição: Volume 162, Nº 3 (2017)
- Páginas: 362-365
- Seção: Microbiology and Immunology
- URL: https://journals.rcsi.science/0007-4888/article/view/238209
- DOI: https://doi.org/10.1007/s10517-017-3616-2
- ID: 238209
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Resumo
We studied the effect of carbon monoxide (60-, 75-, and 90-min exposure) on the expression of antiapoptotic proteins (survivin and Bcl-2) in human blood lymphocytes in the presence of recombinant IL-2 in an apoptosis-inducing dose (0.1 ng/ml). Incubation of cells in atmosphere with carbon monoxide in the presence of recombinant IL-2 was accompanied by accumulation of Bcl-2 protein with simultaneous decrease of survivin content. It was concluded that carbon monoxide plays a role in the dysregulation of apoptosis of human blood lymphocytes Bcl-2 (i.e. CO inhibits the proapoptotic effect of recombinant IL-2).
Sobre autores
V. Artyukhov
Voronezh State University
Autor responsável pela correspondência
Email: artyukhov@bio.vsu.ru
Rússia, Voronezh
O. Tyunina
N. N. Burdenko Voronezh State Medical University
Email: artyukhov@bio.vsu.ru
Rússia, Voronezh
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