Changes in Respiratory Function during Treatment with Combination of Analgesic Substances Trimeperidine and Dexmedetomidine
- Autores: Yudin M.1, Vengerovich N.1, Sagalov G.1, Vahvijanen M.2, Bykov V.1, Chepur S.1
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Afiliações:
- State Research Testing Institute of Military Medicine, Ministry of Defense of the Russian Federation
- Innovative Pharmaceutical Company Silver Farm
- Edição: Volume 162, Nº 2 (2016)
- Páginas: 215-219
- Seção: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/238046
- DOI: https://doi.org/10.1007/s10517-016-3579-8
- ID: 238046
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Resumo
The effects of analgesic substances trimeperidine and dexmedetomidine and their combinations in different proportions (0.75:0.25, 0.5:0.5, 0.25:0.75 of the medium effective doses of each substance) on respiratory function was studied in experiments on rats. Administration of substances in 1 ED50 by analgesic effect (corresponded to medium therapeutic dose of trimeperidine in humans) was characterized by significantly longer suppression of respiration over 90 min in comparison with combined treatment with these substances. Administration of the substances in a dose of 8 ED50 by analgesic effect (corresponded to daily therapeutic dose) over 60 min was followed by more than 3-fold reduction in respiration frequency and respiratory minute volume, more pronounced in animals receiving trimeperidine. Combined administration of these drugs in the specifi ed dose induced less pronounced suppression of respiration and combined administration of trimeperidine and dexmedetomidine in proportion of 0.75:0.25 signifi cantly reduced the period of restoration of respiratory parameters in comparison with animals receiving single substances.
Sobre autores
M. Yudin
State Research Testing Institute of Military Medicine, Ministry of Defense of the Russian Federation
Email: ng@vengerovich.ru
Rússia, St. Petersburg
N. Vengerovich
State Research Testing Institute of Military Medicine, Ministry of Defense of the Russian Federation
Autor responsável pela correspondência
Email: ng@vengerovich.ru
Rússia, St. Petersburg
G. Sagalov
State Research Testing Institute of Military Medicine, Ministry of Defense of the Russian Federation
Email: ng@vengerovich.ru
Rússia, St. Petersburg
M. Vahvijanen
Innovative Pharmaceutical Company Silver Farm
Email: ng@vengerovich.ru
Rússia, St. Petersburg
V. Bykov
State Research Testing Institute of Military Medicine, Ministry of Defense of the Russian Federation
Email: ng@vengerovich.ru
Rússia, St. Petersburg
S. Chepur
State Research Testing Institute of Military Medicine, Ministry of Defense of the Russian Federation
Email: ng@vengerovich.ru
Rússia, St. Petersburg