Selank Inhibits Ethanol-Induced Hyperlocomotion and Manifestation of Behavioral Sensitization in DBA/2 Mice
- Autores: Kolik L.1, Nadorova A.1, Seredenin S.1
-
Afiliações:
- V. V. Zakusov Research Institute of Pharmacology
- Edição: Volume 162, Nº 1 (2016)
- Páginas: 56-59
- Seção: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/237899
- DOI: https://doi.org/10.1007/s10517-016-3544-6
- ID: 237899
Citar
Resumo
The effect of non-benzodiazepine anxiolytics on the ethanol-induced hyperlocomotion and behavioral sensitization was assessed in male DBA/2 mice. Selank that enhances activity of the endogenous opioid system (0.3 mg/kg, intraperitoneally), similar to the nonselective opiate receptor blocker naloxone (1.0 mg/kg, intraperitoneally), prevented the development of ethanol-induced (2.0 g/kg intraperitoneally) hyperlocomotion, in contrast to σ1-receptors agonist Afobazole (1.0 mg/kg, intraperitoneally) that did not inhibit ethanol-induced behavioral stimulation. Single dose of Selank significantly blocked manifestation of motor sensitization without affecting its formation. These findings suggest that Selank can modulate the motivational effects of ethanol.
Sobre autores
L. Kolik
V. V. Zakusov Research Institute of Pharmacology
Autor responsável pela correspondência
Email: lgkolik@mail.ru
Rússia, Moscow
A. Nadorova
V. V. Zakusov Research Institute of Pharmacology
Email: lgkolik@mail.ru
Rússia, Moscow
S. Seredenin
V. V. Zakusov Research Institute of Pharmacology
Email: lgkolik@mail.ru
Rússia, Moscow
![](/img/style/loading.gif)