Different Efficiency of Liposomal Forms with Hydrophilic and Hydrophobic Antitumor Agents in Relation to Solid Transplants of Mouse Tumor and Its Metastases in the Liver
- Autores: Popova N.1,2, Kaledin V.1, Nikolin V.1, Bogdanova L.3, Morozkova T.3, Tornuev Y.3
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Afiliações:
- Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
- Novosibirsk National Research University
- Institute of Molecular Pathology and Pathomorphology
- Edição: Volume 161, Nº 6 (2016)
- Páginas: 811-815
- Seção: Oncology
- URL: https://journals.rcsi.science/0007-4888/article/view/237805
- DOI: https://doi.org/10.1007/s10517-016-3518-8
- ID: 237805
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Resumo
Experiments were performed on the model of transplanted mouse tumor with high incidence of liver metastases. Hydrophilic drug cycloplatam (injected intravenously in liposomes) was more potent than “free cycloplatam” (injected intravenously or intraperitoneally in physiological saline) in inhibiting the growth of natural and experimental metastases in the liver. By contrast, liposomal cycloplatam had lower efficiency than free cycloplatam in suppressing the growth of solid tumor. Liposomal and free cortifen (hydrophobic hormonal cytostatic) produced nearly the same effects on solid tumor growth. Our results suggest that liposomal forms of hydrophobic compounds producing nonselective effect on tumor cells (e.g., actinomycin D or Cosmegen), should not have advantages over free forms.
Sobre autores
N. Popova
Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences; Novosibirsk National Research University
Autor responsável pela correspondência
Email: pathol@inbox.ru
Rússia, Novosibirsk; Novosibirsk
V. Kaledin
Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: pathol@inbox.ru
Rússia, Novosibirsk
V. Nikolin
Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: pathol@inbox.ru
Rússia, Novosibirsk
L. Bogdanova
Institute of Molecular Pathology and Pathomorphology
Email: pathol@inbox.ru
Rússia, Novosibirsk
T. Morozkova
Institute of Molecular Pathology and Pathomorphology
Email: pathol@inbox.ru
Rússia, Novosibirsk
Yu. Tornuev
Institute of Molecular Pathology and Pathomorphology
Email: pathol@inbox.ru
Rússia, Novosibirsk