Different Efficiency of Liposomal Forms with Hydrophilic and Hydrophobic Antitumor Agents in Relation to Solid Transplants of Mouse Tumor and Its Metastases in the Liver
- Authors: Popova N.A.1,2, Kaledin V.I.1, Nikolin V.P.1, Bogdanova L.A.3, Morozkova T.S.3, Tornuev Y.V.3
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Affiliations:
- Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
- Novosibirsk National Research University
- Institute of Molecular Pathology and Pathomorphology
- Issue: Vol 161, No 6 (2016)
- Pages: 811-815
- Section: Oncology
- URL: https://journals.rcsi.science/0007-4888/article/view/237805
- DOI: https://doi.org/10.1007/s10517-016-3518-8
- ID: 237805
Cite item
Abstract
Experiments were performed on the model of transplanted mouse tumor with high incidence of liver metastases. Hydrophilic drug cycloplatam (injected intravenously in liposomes) was more potent than “free cycloplatam” (injected intravenously or intraperitoneally in physiological saline) in inhibiting the growth of natural and experimental metastases in the liver. By contrast, liposomal cycloplatam had lower efficiency than free cycloplatam in suppressing the growth of solid tumor. Liposomal and free cortifen (hydrophobic hormonal cytostatic) produced nearly the same effects on solid tumor growth. Our results suggest that liposomal forms of hydrophobic compounds producing nonselective effect on tumor cells (e.g., actinomycin D or Cosmegen), should not have advantages over free forms.
About the authors
N. A. Popova
Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences; Novosibirsk National Research University
Author for correspondence.
Email: pathol@inbox.ru
Russian Federation, Novosibirsk; Novosibirsk
V. I. Kaledin
Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: pathol@inbox.ru
Russian Federation, Novosibirsk
V. P. Nikolin
Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: pathol@inbox.ru
Russian Federation, Novosibirsk
L. A. Bogdanova
Institute of Molecular Pathology and Pathomorphology
Email: pathol@inbox.ru
Russian Federation, Novosibirsk
T. S. Morozkova
Institute of Molecular Pathology and Pathomorphology
Email: pathol@inbox.ru
Russian Federation, Novosibirsk
Yu. V. Tornuev
Institute of Molecular Pathology and Pathomorphology
Email: pathol@inbox.ru
Russian Federation, Novosibirsk