Dynamics of Structural Parameters and Accumulation of Collagen Fibrils in Rat Lung after Inhalations of Surfactant-BL at Various Terms of Bleomycin-Induced Alveolitis


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Resumo

Rats were subjected to surfactant-BL inhalations at the early and late phases of bleomycininduced alveolitis. In both regimens, the drug reduced the severity of inflammation. In the acute phase of alveolitis, the therapeutic effect of inhalation was accompanied by activation of the synthesis of fine lose collagen fibrils. In the late phase of alveolitis, inhalation of surfactant-BL thickened the fibrils and diminished their population in alveolar walls.

Sobre autores

V. Volchkov

Russian Research Center of Radiology and Surgical Technologies, Ministry of Health of the Russian Federation

Autor responsável pela correspondência
Email: volchkov@biosurf.ru
Rússia, St. Petersburg

V. Dubrovskaya

Russian Research Center of Radiology and Surgical Technologies, Ministry of Health of the Russian Federation

Email: volchkov@biosurf.ru
Rússia, St. Petersburg

A. Valkovich

Russian Research Center of Radiology and Surgical Technologies, Ministry of Health of the Russian Federation

Email: volchkov@biosurf.ru
Rússia, St. Petersburg

O. Klestova

Russian Research Center of Radiology and Surgical Technologies, Ministry of Health of the Russian Federation

Email: volchkov@biosurf.ru
Rússia, St. Petersburg

V. Serzhanina

Russian Research Center of Radiology and Surgical Technologies, Ministry of Health of the Russian Federation

Email: volchkov@biosurf.ru
Rússia, St. Petersburg

A. Zhuikov

Russian Research Center of Radiology and Surgical Technologies, Ministry of Health of the Russian Federation

Email: volchkov@biosurf.ru
Rússia, St. Petersburg

A. Seiliev

Russian Research Center of Radiology and Surgical Technologies, Ministry of Health of the Russian Federation

Email: volchkov@biosurf.ru
Rússia, St. Petersburg

O. Rosenberg

Russian Research Center of Radiology and Surgical Technologies, Ministry of Health of the Russian Federation

Email: volchkov@biosurf.ru
Rússia, St. Petersburg

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