Dynamics of Structural Parameters and Accumulation of Collagen Fibrils in Rat Lung after Inhalations of Surfactant-BL at Various Terms of Bleomycin-Induced Alveolitis
- Autores: Volchkov V.A.1, Dubrovskaya V.F.1, Valkovich A.A.1, Klestova O.V.1, Serzhanina V.A.1, Zhuikov A.G.1, Seiliev A.A.1, Rosenberg O.A.1
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Afiliações:
- Russian Research Center of Radiology and Surgical Technologies, Ministry of Health of the Russian Federation
- Edição: Volume 161, Nº 4 (2016)
- Páginas: 465-467
- Seção: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/237518
- DOI: https://doi.org/10.1007/s10517-016-3439-6
- ID: 237518
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Resumo
Rats were subjected to surfactant-BL inhalations at the early and late phases of bleomycininduced alveolitis. In both regimens, the drug reduced the severity of inflammation. In the acute phase of alveolitis, the therapeutic effect of inhalation was accompanied by activation of the synthesis of fine lose collagen fibrils. In the late phase of alveolitis, inhalation of surfactant-BL thickened the fibrils and diminished their population in alveolar walls.
Sobre autores
V. Volchkov
Russian Research Center of Radiology and Surgical Technologies, Ministry of Health of the Russian Federation
Autor responsável pela correspondência
Email: volchkov@biosurf.ru
Rússia, St. Petersburg
V. Dubrovskaya
Russian Research Center of Radiology and Surgical Technologies, Ministry of Health of the Russian Federation
Email: volchkov@biosurf.ru
Rússia, St. Petersburg
A. Valkovich
Russian Research Center of Radiology and Surgical Technologies, Ministry of Health of the Russian Federation
Email: volchkov@biosurf.ru
Rússia, St. Petersburg
O. Klestova
Russian Research Center of Radiology and Surgical Technologies, Ministry of Health of the Russian Federation
Email: volchkov@biosurf.ru
Rússia, St. Petersburg
V. Serzhanina
Russian Research Center of Radiology and Surgical Technologies, Ministry of Health of the Russian Federation
Email: volchkov@biosurf.ru
Rússia, St. Petersburg
A. Zhuikov
Russian Research Center of Radiology and Surgical Technologies, Ministry of Health of the Russian Federation
Email: volchkov@biosurf.ru
Rússia, St. Petersburg
A. Seiliev
Russian Research Center of Radiology and Surgical Technologies, Ministry of Health of the Russian Federation
Email: volchkov@biosurf.ru
Rússia, St. Petersburg
O. Rosenberg
Russian Research Center of Radiology and Surgical Technologies, Ministry of Health of the Russian Federation
Email: volchkov@biosurf.ru
Rússia, St. Petersburg
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