IFN-α, IFN-β, and IFN-γ Have Different Effect on the Production of Proinflammatory Factors Deposited in Weibel-Palade Bodies of Endothelial Cells Infected with Herpes Simplex Virus Type 1
- Autores: Shcheglovitova O.1, Boldyreva N.1, Sklyankina N.1, Babayants A.1, Frolova I.1
-
Afiliações:
- N. F. Gamalea Institute of Epidemiology and Microbiology, Ministry of Health of the Russian Federation
- Edição: Volume 161, Nº 2 (2016)
- Páginas: 270-275
- Seção: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/237327
- DOI: https://doi.org/10.1007/s10517-016-3393-3
- ID: 237327
Citar
Resumo
We demonstrated similarities and differences in the effects of IFN-α and IFN-β compared to IFN-γ on the production of factors deposited in the Weibel-Palade bodies in cultures of endothelial cells (intact and infected with herpes simplex virus 1). IFN-α and IFN-β reduced the content of von Willebrand factor, endothelin-1, and soluble P-selectin and increased IL-8 concentration in the culture medium of human umbilical vein endothelial cells. IFN-γ reduced the content of all studied factors in the endothelial cell culture medium. Possible mechanisms of these effects are discussed.
Sobre autores
O. Shcheglovitova
N. F. Gamalea Institute of Epidemiology and Microbiology, Ministry of Health of the Russian Federation
Autor responsável pela correspondência
Email: scheglovitova@rambler.ru
Rússia, Moscow
N. Boldyreva
N. F. Gamalea Institute of Epidemiology and Microbiology, Ministry of Health of the Russian Federation
Email: scheglovitova@rambler.ru
Rússia, Moscow
N. Sklyankina
N. F. Gamalea Institute of Epidemiology and Microbiology, Ministry of Health of the Russian Federation
Email: scheglovitova@rambler.ru
Rússia, Moscow
A. Babayants
N. F. Gamalea Institute of Epidemiology and Microbiology, Ministry of Health of the Russian Federation
Email: scheglovitova@rambler.ru
Rússia, Moscow
I. Frolova
N. F. Gamalea Institute of Epidemiology and Microbiology, Ministry of Health of the Russian Federation
Email: scheglovitova@rambler.ru
Rússia, Moscow