Toxicogenomic Effects in Rat Blood Leukocytes and Chemoprophylaxis of Radiation-Induced Carcinogenesis
- Autores: Ivanov S.1, Bespalov V.1, Semenov A.1, Kovan’ko E.1, Aleksandrov V.2
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Afiliações:
- Russian Research Center of Radiology and Surgical Technologies, Ministry of Health of the Russian Federation
- N. N. Petrov Research Institute of Oncology, Ministry of Health of the Russian Federation
- Edição: Volume 160, Nº 5 (2016)
- Páginas: 705-708
- Seção: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/236906
- DOI: https://doi.org/10.1007/s10517-016-3255-z
- ID: 236906
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Resumo
Toxicogenomic parameters were studied in the blood of female rats after exposure to ionizing γ-radiation in a dose of 4 Gy and chemoprophylaxis with α-difluoromethylornithine, eleutherococcus or leuzea extracts, which were used in animals with morphological manifestations of tumor growth under conditions of radiation-induced carcinogenesis. Life-time evaluation of toxicogenomic effects was carried out by express method for measurements of blood nucleotid DNA – fluorescent indication. The level of hyperaneu/polyploidy increased in the blood leukocytes of control rats 30 days after radiation exposure. A significant decrease of genotoxicity as a result of drug treatment in comparison with the number and multiplicity of tumors in irradiated animals was found only in the endocrine and reproductive organs of rats treated by eleutherococcus extract.
Sobre autores
S. Ivanov
Russian Research Center of Radiology and Surgical Technologies, Ministry of Health of the Russian Federation
Autor responsável pela correspondência
Email: sergey.d.ivanov@mail.ru
Rússia, St. Petersburg
V. Bespalov
Russian Research Center of Radiology and Surgical Technologies, Ministry of Health of the Russian Federation
Email: sergey.d.ivanov@mail.ru
Rússia, St. Petersburg
A. Semenov
Russian Research Center of Radiology and Surgical Technologies, Ministry of Health of the Russian Federation
Email: sergey.d.ivanov@mail.ru
Rússia, St. Petersburg
E. Kovan’ko
Russian Research Center of Radiology and Surgical Technologies, Ministry of Health of the Russian Federation
Email: sergey.d.ivanov@mail.ru
Rússia, St. Petersburg
V. Aleksandrov
N. N. Petrov Research Institute of Oncology, Ministry of Health of the Russian Federation
Email: sergey.d.ivanov@mail.ru
Rússia, St. Petersburg