Role of Ebola Virus vp24 Protein in Inhibition of Interferonogenesis
- Autores: Shelemba A.1, Lushnikova E.1, Kolesnikov S.2, Nepomnyashchikh L.1, Chepurnov A.2
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Afiliações:
- Institute of Molecular Pathology and Pathomorphology
- Institute of Basic and Clinical Immunology
- Edição: Volume 160, Nº 3 (2016)
- Páginas: 350-352
- Seção: Virology
- URL: https://journals.rcsi.science/0007-4888/article/view/236704
- DOI: https://doi.org/10.1007/s10517-016-3168-x
- ID: 236704
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Resumo
The effects of recombinant analog of natural Ebola virus protein vp24 in configurations virulent (vp24-ad) and avirulent (vp24-w) for guinea pigs on interferonogenesis were studied in vivo and in vitro. Amino acid differences were determined by His186 substitution in avirulent (nonlethal) configuration for Tyr in the virulent (lethal) one. Recombinant analogs vp24-w and vp24-ad inhibited interferonogenesis in vivo and in vitro. Inhibition by the two protein configurations was virtually the same.
Sobre autores
A. Shelemba
Institute of Molecular Pathology and Pathomorphology
Autor responsável pela correspondência
Email: pathol@inbox.eu
Rússia, Novosibirsk
E. Lushnikova
Institute of Molecular Pathology and Pathomorphology
Email: pathol@inbox.eu
Rússia, Novosibirsk
S. Kolesnikov
Institute of Basic and Clinical Immunology
Email: pathol@inbox.eu
Rússia, Novosibirsk
L. Nepomnyashchikh
Institute of Molecular Pathology and Pathomorphology
Email: pathol@inbox.eu
Rússia, Novosibirsk
A. Chepurnov
Institute of Basic and Clinical Immunology
Email: pathol@inbox.eu
Rússia, Novosibirsk