Email this article Role of Ebola Virus vp24 Protein in Inhibition of Interferonogenesis
- Authors: Shelemba A.A.1, Lushnikova E.L.1, Kolesnikov S.I.2, Nepomnyashchikh L.M.1, Chepurnov A.A.2
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Affiliations:
- Institute of Molecular Pathology and Pathomorphology
- Institute of Basic and Clinical Immunology
- Issue: Vol 160, No 3 (2016)
- Pages: 350-352
- Section: Virology
- URL: https://journals.rcsi.science/0007-4888/article/view/236704
- DOI: https://doi.org/10.1007/s10517-016-3168-x
- ID: 236704
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Abstract
The effects of recombinant analog of natural Ebola virus protein vp24 in configurations virulent (vp24-ad) and avirulent (vp24-w) for guinea pigs on interferonogenesis were studied in vivo and in vitro. Amino acid differences were determined by His186 substitution in avirulent (nonlethal) configuration for Tyr in the virulent (lethal) one. Recombinant analogs vp24-w and vp24-ad inhibited interferonogenesis in vivo and in vitro. Inhibition by the two protein configurations was virtually the same.
About the authors
A. A. Shelemba
Institute of Molecular Pathology and Pathomorphology
Author for correspondence.
Email: pathol@inbox.eu
Russian Federation, Novosibirsk
E. L. Lushnikova
Institute of Molecular Pathology and Pathomorphology
Email: pathol@inbox.eu
Russian Federation, Novosibirsk
S. I. Kolesnikov
Institute of Basic and Clinical Immunology
Email: pathol@inbox.eu
Russian Federation, Novosibirsk
L. M. Nepomnyashchikh
Institute of Molecular Pathology and Pathomorphology
Email: pathol@inbox.eu
Russian Federation, Novosibirsk
A. A. Chepurnov
Institute of Basic and Clinical Immunology
Email: pathol@inbox.eu
Russian Federation, Novosibirsk
