Human Umbilical Cord Blood Serum/Plasma: Cytokine Profile and Prospective Application in Regenerative Medicine
- Авторлар: Romanov Y.1,2, Vtorushina V.3, Dugina T.2, Romanov A.3, Petrova N.2
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Мекемелер:
- National Medical Research Center of Cardiology, Ministry of Health of the Russian Federation
- CryoCenter Cord Blood Bank
- V. I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation
- Шығарылым: Том 168, № 1 (2019)
- Беттер: 173-177
- Бөлім: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/242341
- DOI: https://doi.org/10.1007/s10517-019-04670-2
- ID: 242341
Дәйексөз келтіру
Аннотация
The concentrations of cytokines and growth factors in human umbilical cord blood serum and plasma samples were measured by multiplex analysis. It was found that in comparison with peripheral blood serum of adult donors, umbilical cord blood serum and plasma contain significantly higher concentrations of the most studied molecules including IL-4, 5, 6, 7, 10 and 15, MCP-1, SCF, and SDF, as well as growth factors directly involved in the processes of regeneration (G-CSF, HGF, PDGF-BB, and VEGF). Thus, umbilical cord blood plasma and especially serum are a rich source of cytokines and growth factors with anti-inflammatory, anti-apoptotic, and angiogenic effects and can be used in various fields of regenerative medicine.
Авторлар туралы
Yu. Romanov
National Medical Research Center of Cardiology, Ministry of Health of the Russian Federation; CryoCenter Cord Blood Bank
Хат алмасуға жауапты Автор.
Email: romanov@cryocenter.ru
Ресей, Moscow; Moscow
V. Vtorushina
V. I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation
Email: romanov@cryocenter.ru
Ресей, Moscow
T. Dugina
CryoCenter Cord Blood Bank
Email: romanov@cryocenter.ru
Ресей, Moscow
A. Romanov
V. I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation
Email: romanov@cryocenter.ru
Ресей, Moscow
N. Petrova
CryoCenter Cord Blood Bank
Email: romanov@cryocenter.ru
Ресей, Moscow