Human Umbilical Cord Blood Serum/Plasma: Cytokine Profile and Prospective Application in Regenerative Medicine
- Authors: Romanov Y.A.1,2, Vtorushina V.V.3, Dugina T.N.2, Romanov A.Y.3, Petrova N.V.2
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Affiliations:
- National Medical Research Center of Cardiology, Ministry of Health of the Russian Federation
- CryoCenter Cord Blood Bank
- V. I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation
- Issue: Vol 168, No 1 (2019)
- Pages: 173-177
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/242341
- DOI: https://doi.org/10.1007/s10517-019-04670-2
- ID: 242341
Cite item
Abstract
The concentrations of cytokines and growth factors in human umbilical cord blood serum and plasma samples were measured by multiplex analysis. It was found that in comparison with peripheral blood serum of adult donors, umbilical cord blood serum and plasma contain significantly higher concentrations of the most studied molecules including IL-4, 5, 6, 7, 10 and 15, MCP-1, SCF, and SDF, as well as growth factors directly involved in the processes of regeneration (G-CSF, HGF, PDGF-BB, and VEGF). Thus, umbilical cord blood plasma and especially serum are a rich source of cytokines and growth factors with anti-inflammatory, anti-apoptotic, and angiogenic effects and can be used in various fields of regenerative medicine.
About the authors
Yu. A. Romanov
National Medical Research Center of Cardiology, Ministry of Health of the Russian Federation; CryoCenter Cord Blood Bank
Author for correspondence.
Email: romanov@cryocenter.ru
Russian Federation, Moscow; Moscow
V. V. Vtorushina
V. I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation
Email: romanov@cryocenter.ru
Russian Federation, Moscow
T. N. Dugina
CryoCenter Cord Blood Bank
Email: romanov@cryocenter.ru
Russian Federation, Moscow
A. Yu. Romanov
V. I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation
Email: romanov@cryocenter.ru
Russian Federation, Moscow
N. V. Petrova
CryoCenter Cord Blood Bank
Email: romanov@cryocenter.ru
Russian Federation, Moscow