Morphological Changes in the Retina Under Conditions of Experimental In Vivo Regional Ischemia/Reperfusion
- Авторлар: Kiseleva T.1, Chudin A.1, Khoroshilova-Maslova I.1, Shchipanova A.1, Maibogin A.1, Zaitsev M.1
-
Мекемелер:
- Helmholtz Moscow Research Institute of Eye Diseases, Ministry of Health of the Russian Federation
- Шығарылым: Том 167, № 2 (2019)
- Беттер: 287-292
- Бөлім: Morphology and Pathomorphology
- URL: https://journals.rcsi.science/0007-4888/article/view/241655
- DOI: https://doi.org/10.1007/s10517-019-04511-2
- ID: 241655
Дәйексөз келтіру
Аннотация
Two models of retinal ischemia/reperfusion were developed in an experiment on rats and structural changes in eye tissues in the early and late postischemic periods were studied. Ischemia/reperfusion was modeled by elevation of intraocular pressure to 110 mm Hg for 30 min with air injection into the anterior chamber of the eye with a special device or subconjunctival administration of 0.2 ml 4×10–6 M endothelin-1. Morphological studies of the retina of enucleated eyes were performed in 3, 7, and 30 days after ischemia/reperfusion. In 3 days, signs of retinal ischemia were seen (retinal edema and ganglion cell damage). In the late post-ischemic period (30 days), atrophy of the outer nuclear and outer plexiform layer of the retina was observed in animals with retinal ischemia/reperfusion caused by intraocular pressure elevation and complete destruction of neuronal cells was found after administration of endothelin-1.
Авторлар туралы
T. Kiseleva
Helmholtz Moscow Research Institute of Eye Diseases, Ministry of Health of the Russian Federation
Хат алмасуға жауапты Автор.
Email: tkiseleva05@gmail.com
Ресей, Moscow
A. Chudin
Helmholtz Moscow Research Institute of Eye Diseases, Ministry of Health of the Russian Federation
Email: tkiseleva05@gmail.com
Ресей, Moscow
I. Khoroshilova-Maslova
Helmholtz Moscow Research Institute of Eye Diseases, Ministry of Health of the Russian Federation
Email: tkiseleva05@gmail.com
Ресей, Moscow
A. Shchipanova
Helmholtz Moscow Research Institute of Eye Diseases, Ministry of Health of the Russian Federation
Email: tkiseleva05@gmail.com
Ресей, Moscow
A. Maibogin
Helmholtz Moscow Research Institute of Eye Diseases, Ministry of Health of the Russian Federation
Email: tkiseleva05@gmail.com
Ресей, Moscow
M. Zaitsev
Helmholtz Moscow Research Institute of Eye Diseases, Ministry of Health of the Russian Federation
Email: tkiseleva05@gmail.com
Ресей, Moscow