Effect of NO Synthesis Blockade on the Hydrouretic Function and Extracellular Matrix of the Kidneys in Rats with Different Blood Vasopressin Levels
- Авторлар: Pravikova P.1, Lavrinenko V.2, Ivanova L.1,2
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Мекемелер:
- Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
- Novosibirsk National Research State University
- Шығарылым: Том 167, № 2 (2019)
- Беттер: 233-236
- Бөлім: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/241608
- DOI: https://doi.org/10.1007/s10517-019-04498-w
- ID: 241608
Дәйексөз келтіру
Аннотация
We studied the effect of NO synthesis blockade on the hydrouretic function and the state of renal interstitial matrix in WAG rats with normal blood vasopressin level and Brattleboro rats lacking endogenous vasopressin. In WAG rats, impaired osmotic concentration accompanied by an increase in the content of histochemically detectable glycosaminoglycans in the inner medullary interstitium was observed under conditions of NO synthesis blockade. In Brattleboro rats, NO synthesis inhibition, on the contrary, induced an antidiuretic response without significant changes in the renal extracellular matrix. These findings attested to a significant influence of NO on the urine concentration process. Morphofunctional changes in the kidneys under conditions of NO synthesis blockade are determined by blood vasopressin level.
Авторлар туралы
P. Pravikova
Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Хат алмасуға жауапты Автор.
Email: pollypravi@yandex.ru
Ресей, Novosibirsk
V. Lavrinenko
Novosibirsk National Research State University
Email: pollypravi@yandex.ru
Ресей, Novosibirsk
L. Ivanova
Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences; Novosibirsk National Research State University
Email: pollypravi@yandex.ru
Ресей, Novosibirsk; Novosibirsk
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