Effect of NO Synthesis Blockade on the Hydrouretic Function and Extracellular Matrix of the Kidneys in Rats with Different Blood Vasopressin Levels
- Authors: Pravikova P.D.1, Lavrinenko V.А.2, Ivanova L.N.1,2
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Affiliations:
- Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
- Novosibirsk National Research State University
- Issue: Vol 167, No 2 (2019)
- Pages: 233-236
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/241608
- DOI: https://doi.org/10.1007/s10517-019-04498-w
- ID: 241608
Cite item
Abstract
We studied the effect of NO synthesis blockade on the hydrouretic function and the state of renal interstitial matrix in WAG rats with normal blood vasopressin level and Brattleboro rats lacking endogenous vasopressin. In WAG rats, impaired osmotic concentration accompanied by an increase in the content of histochemically detectable glycosaminoglycans in the inner medullary interstitium was observed under conditions of NO synthesis blockade. In Brattleboro rats, NO synthesis inhibition, on the contrary, induced an antidiuretic response without significant changes in the renal extracellular matrix. These findings attested to a significant influence of NO on the urine concentration process. Morphofunctional changes in the kidneys under conditions of NO synthesis blockade are determined by blood vasopressin level.
About the authors
P. D. Pravikova
Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Author for correspondence.
Email: pollypravi@yandex.ru
Russian Federation, Novosibirsk
V. А. Lavrinenko
Novosibirsk National Research State University
Email: pollypravi@yandex.ru
Russian Federation, Novosibirsk
L. N. Ivanova
Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences; Novosibirsk National Research State University
Email: pollypravi@yandex.ru
Russian Federation, Novosibirsk; Novosibirsk
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