Status of the Microcirculatory Network as a Factor of Prognosis and Evaluation of Therapeutic Efficiency in Prostate Cancer Treated by High-Intensity Focused Ultrasound in Combination with Androgen Deprivation
- Авторлар: Bakarev M.1, Levin V.2, Kachesov I.1, Abdullaev N.1, Neimark A.2
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Мекемелер:
- Institute of Molecular Pathology and Pathomorphology
- Altai State Medical University, Ministry of Health of Russia
- Шығарылым: Том 165, № 5 (2018)
- Беттер: 682-687
- Бөлім: Oncology
- URL: https://journals.rcsi.science/0007-4888/article/view/240667
- DOI: https://doi.org/10.1007/s10517-018-4241-4
- ID: 240667
Дәйексөз келтіру
Аннотация
Immunohistochemical and morphometric analysis of the microcirculatory bed in the tumor and non-tumor parenchyma of the prostate was carried out with the use of endothelial cell marker CD34 in patients treated by high-intensity focused ultrasound (HIFU). The numerical density of microvessels in the adenocarcinoma focus did not correlate with the degree of its differentiation, while high values of this parameter were associated with lower incidence of local progression after HIFU. Effective HIFU ablation led to progressive fibrosis and significant reduction of the microcirculatory bed in zones of intact non-tumor glands in control samples; an inverse relationship between the degree of reduction of the microcirculatory bed and the probability of relapse was revealed. The use of HIFU in combination with androgen deprivation was associated with a decrease in numerical density of microvessels in zones of tumor and non-tumor parenchyma in patients with relapses.
Авторлар туралы
M. Bakarev
Institute of Molecular Pathology and Pathomorphology
Хат алмасуға жауапты Автор.
Email: pathol@inbox.ru
Ресей, Novosibirsk
V. Levin
Altai State Medical University, Ministry of Health of Russia
Email: pathol@inbox.ru
Ресей, Barnaul
I. Kachesov
Institute of Molecular Pathology and Pathomorphology
Email: pathol@inbox.ru
Ресей, Novosibirsk
N. Abdullaev
Institute of Molecular Pathology and Pathomorphology
Email: pathol@inbox.ru
Ресей, Novosibirsk
A. Neimark
Altai State Medical University, Ministry of Health of Russia
Email: pathol@inbox.ru
Ресей, Barnaul
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