Protective Role of Nitrate/Nitrite Reductase System during Transient Global Cerebral Ischemia
- Авторлар: Kuzenkov V.1
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Мекемелер:
- Faculty of Biology, M. V. Lomonosov Moscow State University
- Шығарылым: Том 165, № 1 (2018)
- Беттер: 31-35
- Бөлім: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/239948
- DOI: https://doi.org/10.1007/s10517-018-4092-z
- ID: 239948
Дәйексөз келтіру
Аннотация
The effects of a non-selective blocker of NO synthases LNNA in a dose of 25 mg/kg and nitrates KNO3, NaNO3, Mg(NO3)2, and Ca(NO3)2 in doses of 5 and 50 mg/kg were studied on the model of experimental ischemic stroke induced by bilateral occlusion of the common carotid arteries. Wistar rats were randomized into 40 treatment (n=960) and 8 control (n=192) groups. Treatment group rats received injection of either nitrate, or LNNA, or a combination LNNA+nitrate. All substances were administered intraperitoneally 1 h prior to brain ischemia or 5 sec after occlusion of the common carotid arteries. Control rats received the same volume of 0.9% NaCl at the same terms. The non-selective inhibitor of NO synthases LNNA administered against the background of brain ischemia increased neurological deficit and animal mortality. Nitrate/nitrite reductase system had protective properties depending on the cation of nitrate and concentration of a nitrate during inhibition of NO synthase system under conditions of brain ischemia and hypoxia.
Авторлар туралы
V. Kuzenkov
Faculty of Biology, M. V. Lomonosov Moscow State University
Хат алмасуға жауапты Автор.
Email: kouzenkov@mail.ru
Ресей, Moscow