Cellular Composition of the B- and T-Cell-Dependent Areas in the Small Intestine during the Post-Stress Period (Experimental Study)
- Авторлар: Koplik E.1, Ivanova E.1, Pertsov S.1,2
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Мекемелер:
- P. K. Anokhin Research Institute of Normal Physiology
- A. I. Evdokimov Moscow State Medical and Dental University, Ministry of Health of the Russian Federation
- Шығарылым: Том 164, № 4 (2018)
- Беттер: 413-419
- Бөлім: General Pathology and Pathophysiology
- URL: https://journals.rcsi.science/0007-4888/article/view/239660
- DOI: https://doi.org/10.1007/s10517-018-4002-4
- ID: 239660
Дәйексөз келтіру
Аннотация
A quantitative study of lymphoid cells in the B- and T-cell-dependent areas of intestinal lymphoid nodules and mesenteric lymph nodes in behaviorally passive and active rats was performed at various periods after acute stress on the model of 1-h immobilization with simultaneous electrocutaneous stimulation. Stress exposure is accompanied by a decrease in the number of lymphoid cells in immunogenic structures of the gastrointestinal tract. Post-stress changes in the cytoarchitectonics of B- and T-cell-dependent areas in mesenteric lymph nodes of animals are less pronounced than in lymphoid nodules. Quantitative changes in lymphoid cells of B-cell-dependent areas in the small intestine of rats are greater than in T-cell-dependent areas. Changes in the cellular composition of immunogenic structures in the digestive system are most significant at the early stages of the post-stress period (1st week). Passive rats are characterized by significant changes in the cytoarchitectonics of B- and Tcell-dependent areas in the small intestine after extreme exposure, which illustrates functional exhaustion of the lymphoid tissue in stress-predisposed specimens.
Авторлар туралы
E. Koplik
P. K. Anokhin Research Institute of Normal Physiology
Email: elena.al.ivanova@gmail.com
Ресей, Moscow
E. Ivanova
P. K. Anokhin Research Institute of Normal Physiology
Хат алмасуға жауапты Автор.
Email: elena.al.ivanova@gmail.com
Ресей, Moscow
S. Pertsov
P. K. Anokhin Research Institute of Normal Physiology; A. I. Evdokimov Moscow State Medical and Dental University, Ministry of Health of the Russian Federation
Email: elena.al.ivanova@gmail.com
Ресей, Moscow; Moscow