Delayed Results of Experimental Afobazole Therapy in Rats after Acute Myocardial Infarction
- Авторлар: Kryzhanovskii S.1, Tsorin I.1, Stolyaruk V.1, Ionova E.1, Vititnova M.1
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Мекемелер:
- V. V. Zakusov Research Institute of Pharmacology
- Шығарылым: Том 163, № 2 (2017)
- Беттер: 180-183
- Бөлім: General Pathology and Pathophysiology
- URL: https://journals.rcsi.science/0007-4888/article/view/238738
- DOI: https://doi.org/10.1007/s10517-017-3761-7
- ID: 238738
Дәйексөз келтіру
Аннотация
Delayed cardioprotective effects of anxiolytic Afobazole (15 mg/kg, intraperitoneally for 14 days) were evaluated using dynamic echocardiographic recordings on days 2, 15, 56, and 98 after experimental myocardial infarction modeling (rat model of acute myocardial ischemia). The cardiotropic activity of Afobazole is assumed to be related to its agonistic effects on σ1 receptor of cardiomyocytes. It was found that animals treated with Afobazole had no signs of heart failure by the end of observation, as evidenced by left ventricular ejection fraction.
Авторлар туралы
S. Kryzhanovskii
V. V. Zakusov Research Institute of Pharmacology
Хат алмасуға жауапты Автор.
Email: SAK_538@yandex.ru
Ресей, Moscow
I. Tsorin
V. V. Zakusov Research Institute of Pharmacology
Email: SAK_538@yandex.ru
Ресей, Moscow
V. Stolyaruk
V. V. Zakusov Research Institute of Pharmacology
Email: SAK_538@yandex.ru
Ресей, Moscow
E. Ionova
V. V. Zakusov Research Institute of Pharmacology
Email: SAK_538@yandex.ru
Ресей, Moscow
M. Vititnova
V. V. Zakusov Research Institute of Pharmacology
Email: SAK_538@yandex.ru
Ресей, Moscow