Cytokine Production in Mixed Cultures of Mesenchymal Stromal Cells from Wharton’s Jelly and Peripheral Blood Lymphocytes
- Авторлар: Poltavtsev A.1, Poltavtseva R.2, Yushina M.2, Volgina N.1, Svirshchevskaya E.3
-
Мекемелер:
- Institute of Applied Mechanics, Russian Academy of Sciences
- V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation
- M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
- Шығарылым: Том 163, № 1 (2017)
- Беттер: 169-175
- Бөлім: Translated from Kletochnye Tekhnologii v Biologii i Meditsine (Cell Technologies in Biology and Medicine)
- URL: https://journals.rcsi.science/0007-4888/article/view/238732
- DOI: https://doi.org/10.1007/s10517-017-3759-1
- ID: 238732
Дәйексөз келтіру
Аннотация
We compared the production of 19 humoral factors in mixed cultures of mesenchymal stromal cells from Wharton’s jelly and allogenic peripheral blood lymphocytes. For evaluation of the specificity of immunosuppressive activity of mesenchymal stromal cells, comparative analysis of the production of these humoral factors in mixed cultures of lymphocytes and epithelial BxPC-3 cells was conducted. The production of soluble factors in both mono- and mixed cultures significantly correlated (p<0.05). The maximum production was found for proinflammatory chemokine IP-10 and IFN-γ and anti-inflammatory cytokine IL-10. The major difference of mesenchymal stromal cells from epithelial BxPC-3 cells was 7-fold higher production of IL-10, which can explain the immunosuppressive effect of mesenchymal stromal cells.
Авторлар туралы
A. Poltavtsev
Institute of Applied Mechanics, Russian Academy of Sciences
Email: esvir@mx.ibch.ru
Ресей, Moscow
R. Poltavtseva
V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation
Email: esvir@mx.ibch.ru
Ресей, Moscow
M. Yushina
V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation
Email: esvir@mx.ibch.ru
Ресей, Moscow
N. Volgina
Institute of Applied Mechanics, Russian Academy of Sciences
Email: esvir@mx.ibch.ru
Ресей, Moscow
E. Svirshchevskaya
M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Хат алмасуға жауапты Автор.
Email: esvir@mx.ibch.ru
Ресей, Moscow