Structure of Rat Lungs after Administration of Magnetomicelles Based on the Carbon-Coated Iron Nanoparticles
- Авторлар: Vasyukov G.1,2, Sukhodolo I.1, Mil’to I.1,3, Mitrofanova I.1,4
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Мекемелер:
- Department of Morphology and General Pathology, Siberian State Medical University
- Laboratory of Cellular Technologies, Research Institute of Complex Problems of Cardiovascular Diseases
- Department of Biotechnology and Organic Chemistry, National Research Tomsk Polytechnic University
- Laboratory for Translational Cell and Molecular Biomedicine, National Research Tomsk State University
- Шығарылым: Том 163, № 1 (2017)
- Беттер: 99-104
- Бөлім: Morphology and Pathomorphology
- URL: https://journals.rcsi.science/0007-4888/article/view/238682
- DOI: https://doi.org/10.1007/s10517-017-3747-5
- ID: 238682
Дәйексөз келтіру
Аннотация
We studied the effects of single administration of a suspension of magnetomicelles based on carbon-coated iron nanoparticles on the structure of rat lungs within 40 days. Histological analysis revealed a complex of hemodynamic alterations in the lungs. Described changes persisted in the lung stroma from day 1 until day 40, but their intensity decreased by the end of the experiment. Using immunohistochemical Perls reaction we identified cells morphologically corresponding to alveolar and interstitial lung macrophages. The number of Perls+ cells decreased by day 40 of the experiment. Ultrastructural analysis showed endocytosis of modified iron nanoparticles and their accumulation in intracellular digestionorganelles (endo- and lysosomes) of mononuclear phagocyte system cells. Accumulation of magnetomicelles in the lungs was not associated with damage to pneumocytes, macrophages, and blood-air barrier.
Авторлар туралы
G. Vasyukov
Department of Morphology and General Pathology, Siberian State Medical University; Laboratory of Cellular Technologies, Research Institute of Complex Problems of Cardiovascular Diseases
Email: mitrof_@mail.ru
Ресей, Tomsk; Kemerovo
I. Sukhodolo
Department of Morphology and General Pathology, Siberian State Medical University
Email: mitrof_@mail.ru
Ресей, Tomsk
I. Mil’to
Department of Morphology and General Pathology, Siberian State Medical University; Department of Biotechnology and Organic Chemistry, National Research Tomsk Polytechnic University
Email: mitrof_@mail.ru
Ресей, Tomsk; Tomsk
I. Mitrofanova
Department of Morphology and General Pathology, Siberian State Medical University; Laboratory for Translational Cell and Molecular Biomedicine, National Research Tomsk State University
Хат алмасуға жауапты Автор.
Email: mitrof_@mail.ru
Ресей, Tomsk; Tomsk