Cytophysiological Changes in the Follicular Epithelium of the Thyroid Gland after Long-Term Exposure to Low Doses of Dichlorodiphenyltrichloroethane (DDT)
- Авторлар: Yaglova N.1, Yaglov V.1
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Мекемелер:
- Research Institute of Human Morphology
- Шығарылым: Том 162, № 5 (2017)
- Беттер: 699-702
- Бөлім: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/238485
- DOI: https://doi.org/10.1007/s10517-017-3691-4
- ID: 238485
Дәйексөз келтіру
Аннотация
Exposure to endocrine disruptors is considered as a risk factor thyroid gland diseases. We analyzed cytophysiological changes in rat thyroid follicular epithelium after long-term exposure to low doses of the most widespread disruptor DDT. Analysis of thyroid hormone production and light and electron microscopy of thyroid gland samples revealed cytophysiological changes in thyroid epithelium related to impaired transport through the apical membrane, suppressed Golgi complex activity, and impaired thyrotrophic hormone regulation of the secretory functions of thyroid cells, which led to compensatory transition from merocrine to microapocrine secret release.
Авторлар туралы
N. Yaglova
Research Institute of Human Morphology
Хат алмасуға жауапты Автор.
Email: yaglova@mail.ru
Ресей, Moscow
V. Yaglov
Research Institute of Human Morphology
Email: yaglova@mail.ru
Ресей, Moscow
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