Мақаланы E-mail арқылы жіберу Expression of Therapeutic Gene FCU1 Sensitizes Pancreatic Cancer Cells to 5-Fluorocytosine and Enhances the Cytotoxic Effect of 5-Fluorouracil
- Авторлар: Kopantsev E.P.1, Kostina M.B.1, Grankina E.V.2, Kopantseva M.R.1, Egorov V.I.3, Sverdlov E.D.1
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Мекемелер:
- Laboratory of Structure and Functions of Human Genes, M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
- A. V. Vishnevsky Institute of Surgery, Ministry of the Health of the Russian Federation
- Municipal Clinical Hospital No. 5, Moscow City Health Department
- Шығарылым: Том 161, № 6 (2016)
- Беттер: 808-810
- Бөлім: Genetics
- URL: https://journals.rcsi.science/0007-4888/article/view/237803
- DOI: https://doi.org/10.1007/s10517-016-3517-9
- ID: 237803
Дәйексөз келтіру
Ашық рұқсат
Рұқсат берілді
Тек жазылушылар үшін
Аннотация
Hybrid therapeutic gene FCU1 gene was cloned into a lentiviral expression vector and the therapeutic effect of its expression was studied in three pancreatic cancer cell lines. Expression of FCU1 gene sensitized cells of two of three studied pancreatic cancer cell lines to 5-fluorocytosine. In addition, uracil phosphoribosyl transferase activity of the hybrid FCU1 protein increased sensitivity of transfected cells of all three studied pancreatic cancer cell lines to 5-fluorouracil, a standard chemotherapeutic agent.
Авторлар туралы
E. Kopantsev
Laboratory of Structure and Functions of Human Genes, M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Хат алмасуға жауапты Автор.
Email: kopantzev@ibch.ru
Ресей, Moscow
M. Kostina
Laboratory of Structure and Functions of Human Genes, M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: kopantzev@ibch.ru
Ресей, Moscow
E. Grankina
A. V. Vishnevsky Institute of Surgery, Ministry of the Health of the Russian Federation
Email: kopantzev@ibch.ru
Ресей, Moscow
M. Kopantseva
Laboratory of Structure and Functions of Human Genes, M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: kopantzev@ibch.ru
Ресей, Moscow
V. Egorov
Municipal Clinical Hospital No. 5, Moscow City Health Department
Email: kopantzev@ibch.ru
Ресей, Moscow
E. Sverdlov
Laboratory of Structure and Functions of Human Genes, M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: kopantzev@ibch.ru
Ресей, Moscow
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