Pharmacological Correction of Alcohol Motivation Depends on the Phenotype of the Response to Emotional Stress
- Авторлар: Kolik L.1, Gudasheva T.1, Martyanov V.1, Seredenin S.1
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Мекемелер:
- V. V. Zakusov Research Institute of Pharmacology
- Шығарылым: Том 161, № 4 (2016)
- Беттер: 508-512
- Бөлім: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/237548
- DOI: https://doi.org/10.1007/s10517-016-3449-4
- ID: 237548
Дәйексөз келтіру
Аннотация
The specific features of alcohol behavior were studied in MR and MNRA rats that exhibit an opposite reaction to emotional stress. We evaluated the effect of a dipeptide anxiolytic GB-115 (N-phenyl-hexanoyl-glycyl-L-tryptophan amide, neuropeptide cholecystokinin-4 analogue with antagonistic activity) on alcohol motivation in rats, which was formed over 12 months. High-emotionality MR rats were more sensitive to the anxiolytic effect of ethanol in the conflict situation test than low-emotionality MNRA rats. MNRA rats consumed a greater amount of ethanol under a free-choice condition with 15% ethanol solution and water (as in comparison with MR rats). However, the behavior of MR rats was transformed due to a significant increase in alcohol motivation from the 5th month of long-term free access to ethanol. An anxiolytic GB-115 (0.025 mg/kg intraperitoneally for 14 days) with selective activity in high-emotionality rats was shown to reduce significantly the average daily consumption and alcohol-deprivation effect in MR rats, but did not modulate ethanol addiction in MNRA rats.
Авторлар туралы
L. Kolik
V. V. Zakusov Research Institute of Pharmacology
Хат алмасуға жауапты Автор.
Email: lgkoplik@mail.ru
Ресей, Moscow
T. Gudasheva
V. V. Zakusov Research Institute of Pharmacology
Email: lgkoplik@mail.ru
Ресей, Moscow
V. Martyanov
V. V. Zakusov Research Institute of Pharmacology
Email: lgkoplik@mail.ru
Ресей, Moscow
S. Seredenin
V. V. Zakusov Research Institute of Pharmacology
Email: lgkoplik@mail.ru
Ресей, Moscow