Serological Analysis of Immunogenic Properties of Recombinant Meningococcus IgA1 Protease-Based Proteins


Дәйексөз келтіру

Толық мәтін

Ашық рұқсат Ашық рұқсат
Рұқсат жабық Рұқсат берілді
Рұқсат жабық Тек жазылушылар үшін

Аннотация

Using the genome sequence of IgA1 protease of N. meningitidis of serogroup B, four recombinant proteins of different structure and molecular weight were constructed. These proteins were equal in inducing the formation of specific antibodies to IgA1 protease and had protective properties against meningococci. In the sera of immunized mice, anti-IgA1 protease antibodies were detected by whole-cell ELISA, which indicated the presence of IgA1 protease on the surface of these bacteria. We hypothesized that the protective properties of IgA1 protease-based antigens and IgA1 protease analogs could be realized not only via impairment of bacterium adhesion to the mucosa, but also via suppression of this pathogen in the organism. The presented findings seem promising for using these proteins as the basis for anti-meningococcus vaccine.

Авторлар туралы

O. Kotelnikova

M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences

Хат алмасуға жауапты Автор.
Email: ovkot.2003@mail.ru
Ресей, Moscow

A. Zinchenko

M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences

Email: ovkot.2003@mail.ru
Ресей, Moscow

A. Vikhrov

M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences

Email: ovkot.2003@mail.ru
Ресей, Moscow

A. Alliluev

Institute of Medicine, People’s Friendship University of Russia

Email: ovkot.2003@mail.ru
Ресей, Moscow

O. Serova

M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences

Email: ovkot.2003@mail.ru
Ресей, Moscow

E. Gordeeva

M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences

Email: ovkot.2003@mail.ru
Ресей, Moscow

L. Zhigis

M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences

Email: ovkot.2003@mail.ru
Ресей, Moscow

V. Zueva

M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences

Email: ovkot.2003@mail.ru
Ресей, Moscow

O. Razgulyaeva

M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences

Email: ovkot.2003@mail.ru
Ресей, Moscow

T. Melikhova

M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences

Email: ovkot.2003@mail.ru
Ресей, Moscow

E. Nokel

M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences

Email: ovkot.2003@mail.ru
Ресей, Moscow

E. Drozhzhina

M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences

Email: ovkot.2003@mail.ru
Ресей, Moscow

L. Rumsh

M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences

Email: ovkot.2003@mail.ru
Ресей, Moscow


© Springer Science+Business Media New York, 2016

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