Effect of a New Synthetic Peptide Preparation AСTH15-18PGP on the Hemostasis System in Rats
- Authors: Shubina T.A.1, Obergan T.Y.1, Lyapina L.A.1, Grigorieva M.E.1, Myasoedov N.F.2, Andreeva L.A.2
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Affiliations:
- Laboratory of Protective Blood Systems, Faculty of Biology, M. V. Lomonosov Moscow State University
- Institute of Molecular Genetics, Russian Academy of Sciences
- Issue: Vol 168, No 2 (2019)
- Pages: 250-253
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/242386
- DOI: https://doi.org/10.1007/s10517-019-04685-9
- ID: 242386
Cite item
Abstract
We studied the effect of chronic intranasal and peroral administration of a new peptide preparation AСTH15-18PGP in a dose of 100 mg/kg body weight on the state of vascular-platelet and plasma hemostasis in animals. It was found that this synthetic regulatory peptide administered intranasally can produce antiplatelet, anticoagulant, and antifibrin-stabilizing effects on the blood plasma in healthy rats. In both administration routes, the peptide induced activation of the anticoagulation system of the hemostasis by increasing enzymatic and non-enzymatic fibrinolysis; after intranasal administration, the fibrinolytic effects were more pronounced.
About the authors
T. A. Shubina
Laboratory of Protective Blood Systems, Faculty of Biology, M. V. Lomonosov Moscow State University
Author for correspondence.
Email: shubina.74@mail.ru
Russian Federation, Moscow
T. Yu. Obergan
Laboratory of Protective Blood Systems, Faculty of Biology, M. V. Lomonosov Moscow State University
Email: shubina.74@mail.ru
Russian Federation, Moscow
L. A. Lyapina
Laboratory of Protective Blood Systems, Faculty of Biology, M. V. Lomonosov Moscow State University
Email: shubina.74@mail.ru
Russian Federation, Moscow
M. E. Grigorieva
Laboratory of Protective Blood Systems, Faculty of Biology, M. V. Lomonosov Moscow State University
Email: shubina.74@mail.ru
Russian Federation, Moscow
N. F. Myasoedov
Institute of Molecular Genetics, Russian Academy of Sciences
Email: shubina.74@mail.ru
Russian Federation, Moscow
L. A. Andreeva
Institute of Molecular Genetics, Russian Academy of Sciences
Email: shubina.74@mail.ru
Russian Federation, Moscow
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