Effect of a New Synthetic Peptide Preparation AСTH15-18PGP on the Hemostasis System in Rats
- 作者: Shubina T.1, Obergan T.1, Lyapina L.1, Grigorieva M.1, Myasoedov N.2, Andreeva L.2
-
隶属关系:
- Laboratory of Protective Blood Systems, Faculty of Biology, M. V. Lomonosov Moscow State University
- Institute of Molecular Genetics, Russian Academy of Sciences
- 期: 卷 168, 编号 2 (2019)
- 页面: 250-253
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/242386
- DOI: https://doi.org/10.1007/s10517-019-04685-9
- ID: 242386
如何引用文章
详细
We studied the effect of chronic intranasal and peroral administration of a new peptide preparation AСTH15-18PGP in a dose of 100 mg/kg body weight on the state of vascular-platelet and plasma hemostasis in animals. It was found that this synthetic regulatory peptide administered intranasally can produce antiplatelet, anticoagulant, and antifibrin-stabilizing effects on the blood plasma in healthy rats. In both administration routes, the peptide induced activation of the anticoagulation system of the hemostasis by increasing enzymatic and non-enzymatic fibrinolysis; after intranasal administration, the fibrinolytic effects were more pronounced.
作者简介
T. Shubina
Laboratory of Protective Blood Systems, Faculty of Biology, M. V. Lomonosov Moscow State University
编辑信件的主要联系方式.
Email: shubina.74@mail.ru
俄罗斯联邦, Moscow
T. Obergan
Laboratory of Protective Blood Systems, Faculty of Biology, M. V. Lomonosov Moscow State University
Email: shubina.74@mail.ru
俄罗斯联邦, Moscow
L. Lyapina
Laboratory of Protective Blood Systems, Faculty of Biology, M. V. Lomonosov Moscow State University
Email: shubina.74@mail.ru
俄罗斯联邦, Moscow
M. Grigorieva
Laboratory of Protective Blood Systems, Faculty of Biology, M. V. Lomonosov Moscow State University
Email: shubina.74@mail.ru
俄罗斯联邦, Moscow
N. Myasoedov
Institute of Molecular Genetics, Russian Academy of Sciences
Email: shubina.74@mail.ru
俄罗斯联邦, Moscow
L. Andreeva
Institute of Molecular Genetics, Russian Academy of Sciences
Email: shubina.74@mail.ru
俄罗斯联邦, Moscow