Fibroin-Gelatin Composite Stimulates the Regeneration of a Splinted Full-Thickness Skin Wound in Mice
- Authors: Arkhipova A.Y.1,2, Kulikov D.A.2, Moisenovich A.M.1, Andryukhina V.V.2, Chursinova Y.V.2, Filyushkin Y.N.2, Fedulov A.V.2, Bobrov M.A.2, Mosalskaya D.V.2, Glazkova P.A.2, Kulikov A.V.3, Nalivkin A.E.2, Molochkov A.V.2, Semenov D.Y.2
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Affiliations:
- M. V. Lomonosov Moscow State University
- M. F. Vladimirsky Moscow Regional Research and Clinical Institute
- Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
- Issue: Vol 168, No 1 (2019)
- Pages: 95-98
- Section: Biotechnologies
- URL: https://journals.rcsi.science/0007-4888/article/view/242252
- DOI: https://doi.org/10.1007/s10517-019-04656-0
- ID: 242252
Cite item
Abstract
The effects of composite fibroin-gelatin microparticles (100-250 μ) on the rate of wound healing and regeneration under conditions of contraction prevention were studied on the model of splinted full-thickness skin wound in a mouse. Subcutaneous injection of these particles into the defect area accelerated wound healing and promoted re-epithelialization and recovery of normal structure of the epidermis. In addition, the composite microparticles promoted the formation of connective tissue of characteristic structure, replacing the derma over the entire defect, and stimulated regeneration of subcutaneous muscle (panniculus carnosus) and skin appendages (sebaceous glands and hair follicles).
About the authors
A. Yu. Arkhipova
M. V. Lomonosov Moscow State University; M. F. Vladimirsky Moscow Regional Research and Clinical Institute
Author for correspondence.
Email: anastasia-yu.arkhipova@yandex.ru
Russian Federation, Moscow; Moscow
D. A. Kulikov
M. F. Vladimirsky Moscow Regional Research and Clinical Institute
Email: anastasia-yu.arkhipova@yandex.ru
Russian Federation, Moscow
A. M. Moisenovich
M. V. Lomonosov Moscow State University
Email: anastasia-yu.arkhipova@yandex.ru
Russian Federation, Moscow
V. V. Andryukhina
M. F. Vladimirsky Moscow Regional Research and Clinical Institute
Email: anastasia-yu.arkhipova@yandex.ru
Russian Federation, Moscow
Yu. V. Chursinova
M. F. Vladimirsky Moscow Regional Research and Clinical Institute
Email: anastasia-yu.arkhipova@yandex.ru
Russian Federation, Moscow
Yu. N. Filyushkin
M. F. Vladimirsky Moscow Regional Research and Clinical Institute
Email: anastasia-yu.arkhipova@yandex.ru
Russian Federation, Moscow
A. V. Fedulov
M. F. Vladimirsky Moscow Regional Research and Clinical Institute
Email: anastasia-yu.arkhipova@yandex.ru
Russian Federation, Moscow
M. A. Bobrov
M. F. Vladimirsky Moscow Regional Research and Clinical Institute
Email: anastasia-yu.arkhipova@yandex.ru
Russian Federation, Moscow
D. V. Mosalskaya
M. F. Vladimirsky Moscow Regional Research and Clinical Institute
Email: anastasia-yu.arkhipova@yandex.ru
Russian Federation, Moscow
P. A. Glazkova
M. F. Vladimirsky Moscow Regional Research and Clinical Institute
Email: anastasia-yu.arkhipova@yandex.ru
Russian Federation, Moscow
A. V. Kulikov
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
Email: anastasia-yu.arkhipova@yandex.ru
Russian Federation, Moscow
A. E. Nalivkin
M. F. Vladimirsky Moscow Regional Research and Clinical Institute
Email: anastasia-yu.arkhipova@yandex.ru
Russian Federation, Moscow
A. V. Molochkov
M. F. Vladimirsky Moscow Regional Research and Clinical Institute
Email: anastasia-yu.arkhipova@yandex.ru
Russian Federation, Moscow
D. Yu. Semenov
M. F. Vladimirsky Moscow Regional Research and Clinical Institute
Email: anastasia-yu.arkhipova@yandex.ru
Russian Federation, Moscow