Fibroin-Gelatin Composite Stimulates the Regeneration of a Splinted Full-Thickness Skin Wound in Mice
- 作者: Arkhipova A.1,2, Kulikov D.2, Moisenovich A.1, Andryukhina V.2, Chursinova Y.2, Filyushkin Y.2, Fedulov A.2, Bobrov M.2, Mosalskaya D.2, Glazkova P.2, Kulikov A.3, Nalivkin A.2, Molochkov A.2, Semenov D.2
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隶属关系:
- M. V. Lomonosov Moscow State University
- M. F. Vladimirsky Moscow Regional Research and Clinical Institute
- Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
- 期: 卷 168, 编号 1 (2019)
- 页面: 95-98
- 栏目: Biotechnologies
- URL: https://journals.rcsi.science/0007-4888/article/view/242252
- DOI: https://doi.org/10.1007/s10517-019-04656-0
- ID: 242252
如何引用文章
详细
The effects of composite fibroin-gelatin microparticles (100-250 μ) on the rate of wound healing and regeneration under conditions of contraction prevention were studied on the model of splinted full-thickness skin wound in a mouse. Subcutaneous injection of these particles into the defect area accelerated wound healing and promoted re-epithelialization and recovery of normal structure of the epidermis. In addition, the composite microparticles promoted the formation of connective tissue of characteristic structure, replacing the derma over the entire defect, and stimulated regeneration of subcutaneous muscle (panniculus carnosus) and skin appendages (sebaceous glands and hair follicles).
作者简介
A. Arkhipova
M. V. Lomonosov Moscow State University; M. F. Vladimirsky Moscow Regional Research and Clinical Institute
编辑信件的主要联系方式.
Email: anastasia-yu.arkhipova@yandex.ru
俄罗斯联邦, Moscow; Moscow
D. Kulikov
M. F. Vladimirsky Moscow Regional Research and Clinical Institute
Email: anastasia-yu.arkhipova@yandex.ru
俄罗斯联邦, Moscow
A. Moisenovich
M. V. Lomonosov Moscow State University
Email: anastasia-yu.arkhipova@yandex.ru
俄罗斯联邦, Moscow
V. Andryukhina
M. F. Vladimirsky Moscow Regional Research and Clinical Institute
Email: anastasia-yu.arkhipova@yandex.ru
俄罗斯联邦, Moscow
Yu. Chursinova
M. F. Vladimirsky Moscow Regional Research and Clinical Institute
Email: anastasia-yu.arkhipova@yandex.ru
俄罗斯联邦, Moscow
Yu. Filyushkin
M. F. Vladimirsky Moscow Regional Research and Clinical Institute
Email: anastasia-yu.arkhipova@yandex.ru
俄罗斯联邦, Moscow
A. Fedulov
M. F. Vladimirsky Moscow Regional Research and Clinical Institute
Email: anastasia-yu.arkhipova@yandex.ru
俄罗斯联邦, Moscow
M. Bobrov
M. F. Vladimirsky Moscow Regional Research and Clinical Institute
Email: anastasia-yu.arkhipova@yandex.ru
俄罗斯联邦, Moscow
D. Mosalskaya
M. F. Vladimirsky Moscow Regional Research and Clinical Institute
Email: anastasia-yu.arkhipova@yandex.ru
俄罗斯联邦, Moscow
P. Glazkova
M. F. Vladimirsky Moscow Regional Research and Clinical Institute
Email: anastasia-yu.arkhipova@yandex.ru
俄罗斯联邦, Moscow
A. Kulikov
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
Email: anastasia-yu.arkhipova@yandex.ru
俄罗斯联邦, Moscow
A. Nalivkin
M. F. Vladimirsky Moscow Regional Research and Clinical Institute
Email: anastasia-yu.arkhipova@yandex.ru
俄罗斯联邦, Moscow
A. Molochkov
M. F. Vladimirsky Moscow Regional Research and Clinical Institute
Email: anastasia-yu.arkhipova@yandex.ru
俄罗斯联邦, Moscow
D. Semenov
M. F. Vladimirsky Moscow Regional Research and Clinical Institute
Email: anastasia-yu.arkhipova@yandex.ru
俄罗斯联邦, Moscow