Analysis of the Serum Cytokine Profile in Allergic Patients Opens a Way to Personalized Treatment of Allergy
- Authors: Bogdanov I.V.1, Finkina E.I.1, Melnikova D.N.1, Tagaev A.A.1, Ovchinnikova Т.V.1
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Affiliations:
- M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
- Issue: Vol 166, No 6 (2019)
- Pages: 770-773
- Section: Allergology
- URL: https://journals.rcsi.science/0007-4888/article/view/241355
- DOI: https://doi.org/10.1007/s10517-019-04437-9
- ID: 241355
Cite item
Abstract
Plant lipid transfer proteins and homologues of the main birch pollen allergen Bet v 1 are involved in the development of allergic reactions of varying severity to plant foods and pollen. In this study, the sera from patients with tree and weed pollen allergies in the Moscow region were examined. The levels of IL-4, IL-5, IL-9, IL-10, IL-13, IL-17A, IFNγ, TNFα, and TNFβ cytokines were determined in the sera of patients with specific IgE antibodies to Bet v 1 and Pru p 3 allergens. It was confirmed that patients with pollen allergy are often characterized by Th2 response of the immune system, though other mechanisms of allergy development occurred in some cases. The data obtained demonstrate the necessity of detailed analysis of the individual mechanism of allergic reactions and patient-centered approach to the personalized allergy treatment.
About the authors
I. V. Bogdanov
M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: ovch@ibch.ru
Russian Federation, Moscow
E. I. Finkina
M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: ovch@ibch.ru
Russian Federation, Moscow
D. N. Melnikova
M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: ovch@ibch.ru
Russian Federation, Moscow
A. A. Tagaev
M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: ovch@ibch.ru
Russian Federation, Moscow
Т. V. Ovchinnikova
M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Author for correspondence.
Email: ovch@ibch.ru
Russian Federation, Moscow