Markers of Systemic Inflammation in Experimental Dyslipidemia Induced by P-407: Modulation with Fucoidan from Brown Alga Fucus evanescens
- Authors: Kuznetsova T.A.1, Ivanushko L.A.1, Persiyanova E.V.1, Ermakova S.P.2, Besednova N.N.1
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Affiliations:
- G. P. Somov Research Institute of Epidemiology and Microbiology, Far-Eastern Division of the Russian Academy of Sciences
- G. B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Division of the Russian Academy of Sciences
- Issue: Vol 166, No 6 (2019)
- Pages: 766-769
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/241350
- DOI: https://doi.org/10.1007/s10517-019-04436-w
- ID: 241350
Cite item
Abstract
The effect of sulfated polysaccharide from brown alga Fucus evanescens (fucoidan) administered via different routes (peroral and parenteral) on the dynamic of some lipid metabolism parameters and markers of systemic inflammation in mice with experimental dyslipidemia induced by prolonged administration of poloxamer P-407. It was found that fucoidan corrected the main parameters of lipid metabolism, reduced the level of endothelial dysfunction marker endothelin-1 and proinflammatory cytokines TNFα, IFNγ in blood serum in animals with experimental dyslipidemia. These findings open prospects for using fucoidan in the complex treatment of metabolic disorders and atherosclerotic inflammation.
About the authors
T. A. Kuznetsova
G. P. Somov Research Institute of Epidemiology and Microbiology, Far-Eastern Division of the Russian Academy of Sciences
Author for correspondence.
Email: takuznets@mail.ru
Russian Federation, Vladivostok
L. A. Ivanushko
G. P. Somov Research Institute of Epidemiology and Microbiology, Far-Eastern Division of the Russian Academy of Sciences
Email: takuznets@mail.ru
Russian Federation, Vladivostok
E. V. Persiyanova
G. P. Somov Research Institute of Epidemiology and Microbiology, Far-Eastern Division of the Russian Academy of Sciences
Email: takuznets@mail.ru
Russian Federation, Vladivostok
S. P. Ermakova
G. B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Division of the Russian Academy of Sciences
Email: takuznets@mail.ru
Russian Federation, Vladivostok
N. N. Besednova
G. P. Somov Research Institute of Epidemiology and Microbiology, Far-Eastern Division of the Russian Academy of Sciences
Email: takuznets@mail.ru
Russian Federation, Vladivostok