Synthetic Phenolic Antioxidant TS-13 Suppresses the Growth of Lewis Lung Carcinoma and Potentiates Oncolytic Effect of Doxorubicin
- Authors: Men’shchikova E.B.1, Zenkov N.K.1, Kozhin P.M.1, Chechushkov A.V.1, Kovner A.V.1, Khrapova M.V.1, Kandalintseva N.V.2, Martinovich G.G.3
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Affiliations:
- Federal Research Center of Fundamental and Translational Medicine
- Novosibirsk State Pedagogical University
- Belarusian State University
- Issue: Vol 166, No 5 (2019)
- Pages: 646-650
- Section: Oncology
- URL: https://journals.rcsi.science/0007-4888/article/view/241250
- DOI: https://doi.org/10.1007/s10517-019-04410-6
- ID: 241250
Cite item
Abstract
ROS are important intracellular messengers; their ambiguous role in malignant processes was demonstrated in many studies. The effects of a synthetic phenolic antioxidant sodium 3-(3’-tert-butyl-4’-hydroxyphenyl)propyl thiosulfonate sodium (TS-13) on the tumor growth and oncolytic properties of doxorubicin were studied in the experimental model of Lewis lung carcinoma in mice. In mice receiving TS-13 with drinking water (100 mg/kg), suppression of tumor growth by 32.3% was observed on day 21 after inoculation of Lewis lung carcinoma cells. Two-fold intraperitoneal injections of doxorubicin in a cumulative dose of 8 mg/kg were followed by inhibition of tumor growth by 49.5%. Combined treatment with TS-13 and doxorubicin suppressed the tumor growth by 55.4%. In contrast to doxorubicin, TS-13 inhibited NO generation by peritoneal macrophages. The results show the prospect of studying TS-13 in the context of overcoming drug-resistance of tumors.
About the authors
E. B. Men’shchikova
Federal Research Center of Fundamental and Translational Medicine
Author for correspondence.
Email: lemen@centercem.ru
Russian Federation, Novosibirsk
N. K. Zenkov
Federal Research Center of Fundamental and Translational Medicine
Email: lemen@centercem.ru
Russian Federation, Novosibirsk
P. M. Kozhin
Federal Research Center of Fundamental and Translational Medicine
Email: lemen@centercem.ru
Russian Federation, Novosibirsk
A. V. Chechushkov
Federal Research Center of Fundamental and Translational Medicine
Email: lemen@centercem.ru
Russian Federation, Novosibirsk
A. V. Kovner
Federal Research Center of Fundamental and Translational Medicine
Email: lemen@centercem.ru
Russian Federation, Novosibirsk
M. V. Khrapova
Federal Research Center of Fundamental and Translational Medicine
Email: lemen@centercem.ru
Russian Federation, Novosibirsk
N. V. Kandalintseva
Novosibirsk State Pedagogical University
Email: lemen@centercem.ru
Russian Federation, Novosibirsk
G. G. Martinovich
Belarusian State University
Email: lemen@centercem.ru
Belarus, Minsk