Effect of Transcutaneous Electrical Stimulation of Nerves on Blood Pressure and Blood Content of Neuropeptide CGRP and Nitric Oxide in Hypertensive Rats with Metabolic Disturbances
- Authors: Spiridonov V.K.1, Tolochko Z.S.1, Korolenko T.A.1
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Affiliations:
- Research Institute of Physiology and Fundamental Medicine, Siberian Division of the Russian Academy of Medical Sciences
- Issue: Vol 166, No 4 (2019)
- Pages: 436-439
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/241086
- DOI: https://doi.org/10.1007/s10517-019-04367-6
- ID: 241086
Cite item
Abstract
The development of arterial hypertension in male Wistar rats with fructose-induced metabolic syndrome (12.5% of fructose solution as the only drinking source for 10 weeks) along with impaired glucose tolerance and increased serum concentration of triglycerides and LPO products caused a decrease in the content of serum blood calcitonin gene-related peptide (CGRP). Low-frequency transcutaneous electrical nerve stimulation (1 mA, 2 Hz, 10 min daily for 2 weeks) performed in 8 weeks after the beginning of fructose treatment reduced systolic BP and serum concentration of triglycerides and LPO produces and improved glucose tolerance. After stimulation, CGRP content in rats maintained on fructose diet returned to normal values and the content of nitric oxide metabolites increased. We hypothesize that CGRP and nitric oxide are involved in mechanisms mediating the therapeutic effect of low-frequency transcutaneous electrical nerve stimulation on arterial hypertension developing in metabolic syndrome.
About the authors
V. K. Spiridonov
Research Institute of Physiology and Fundamental Medicine, Siberian Division of the Russian Academy of Medical Sciences
Email: toloch@physiol.ru
Russian Federation, Novosibirsk
Z. S. Tolochko
Research Institute of Physiology and Fundamental Medicine, Siberian Division of the Russian Academy of Medical Sciences
Author for correspondence.
Email: toloch@physiol.ru
Russian Federation, Novosibirsk
T. A. Korolenko
Research Institute of Physiology and Fundamental Medicine, Siberian Division of the Russian Academy of Medical Sciences
Email: toloch@physiol.ru
Russian Federation, Novosibirsk
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