Mitochondria-Associated Matrix Metalloproteinases 2 and 9 in Acute Renal Pathologies
- Authors: Pevzner I.B.1,2, Zorova L.D.1,2, Galkin F.A.3, Plotnikov E.Y.1,2,4, Zorov D.B.1,2
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Affiliations:
- A. N. Belozersky Research Institute of Physico-Chemical Biology, M. V. Lomonosov Moscow State University
- V. I. Kulakov National Medical Research Center for Obstetrics, Gynecology, and Perinatology
- Faculty and Bioengineering and Bioinformatics, M. V. Lomonosov Moscow State University
- I. M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of the Russian Federation
- Issue: Vol 166, No 3 (2019)
- Pages: 334-338
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/241001
- DOI: https://doi.org/10.1007/s10517-019-04345-y
- ID: 241001
Cite item
Abstract
Activities of MMP-2 and MMP-9 in the cytoplasm and mitochondria of kidney cells were evaluated on the models of acute renal pathologies: pyelonephritis, rhabdomyolysis, and ischemia/reperfusion of the kidney. In acute pyelonephritis, a significant increase in the level of MMP-2 and MMP-9 in kidney cells and the appearance of mitochondrial MMP-2 isoform with a lower molecular weight, but still exhibiting proteolytic activity were observed. A direct correlation between the level of MMP-2 and MMP-9 in the kidney and the severity of inflammation in pyelonephritis was revealed. Obviously, the appearance of active protease in the mitochondria of the kidney cells could have an impact on their functioning and, generally, on the fate of renal cells in this pathology.
About the authors
I. B. Pevzner
A. N. Belozersky Research Institute of Physico-Chemical Biology, M. V. Lomonosov Moscow State University; V. I. Kulakov National Medical Research Center for Obstetrics, Gynecology, and Perinatology
Email: plotnikov@belozersky.msu.ru
Russian Federation, Moscow; Moscow
L. D. Zorova
A. N. Belozersky Research Institute of Physico-Chemical Biology, M. V. Lomonosov Moscow State University; V. I. Kulakov National Medical Research Center for Obstetrics, Gynecology, and Perinatology
Email: plotnikov@belozersky.msu.ru
Russian Federation, Moscow; Moscow
F. A. Galkin
Faculty and Bioengineering and Bioinformatics, M. V. Lomonosov Moscow State University
Email: plotnikov@belozersky.msu.ru
Russian Federation, Moskva
E. Yu. Plotnikov
A. N. Belozersky Research Institute of Physico-Chemical Biology, M. V. Lomonosov Moscow State University; V. I. Kulakov National Medical Research Center for Obstetrics, Gynecology, and Perinatology; I. M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of the Russian Federation
Author for correspondence.
Email: plotnikov@belozersky.msu.ru
Russian Federation, Moscow; Moscow; Moscow
D. B. Zorov
A. N. Belozersky Research Institute of Physico-Chemical Biology, M. V. Lomonosov Moscow State University; V. I. Kulakov National Medical Research Center for Obstetrics, Gynecology, and Perinatology
Email: plotnikov@belozersky.msu.ru
Russian Federation, Moscow; Moscow