The Dependence of the Mutagenic Effect on the Dose of X-Ray Irradiation in an In Vivo Experiment on Female (CBA×C57Bl/6)F1 Mice
- Authors: Sycheva L.P.1, Shchegoleva R.A.1, Lisina N.I.1, Gordeev A.V.1, Rozhdestvenskii L.M.1
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Affiliations:
- A. I. Burnazyan Federal Medical Biophisical Center, Federal Medical and Biological Agency of the Moscow
- Issue: Vol 166, No 1 (2018)
- Pages: 43-45
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/240816
- DOI: https://doi.org/10.1007/s10517-018-4285-5
- ID: 240816
Cite item
Abstract
We studied the mutagenic effect of X-ray irradiation in doses of 0.5, 1, and 1.5 Gy on female (CBA×C57Bl/6)F1 mice. The mutagenic effect (assessed by the parameter “frequency of bone marrow polychromatophilic erythrocytes with micronuclei”) linearly depended on the dose of X-ray irradiation in the range of up to 1 Gy and reached the plateau at 1.5 Gy. The fraction of polychromatophilic erythrocytes was 45, 45, and 46% under control conditions (without exposure) and exposure to the irradiation in the doses of 0.5 and 1 Gy, respectively. Irradiation in a dose of 1.5 Gy induced a slight inhibition of erythropoiesis. These data confirm the hypothesis on possible death of highly aberrant erythrocyte precursors after irradiation in high doses.
About the authors
L. P. Sycheva
A. I. Burnazyan Federal Medical Biophisical Center, Federal Medical and Biological Agency of the Moscow
Author for correspondence.
Email: lpsycheva@mail.ru
Russian Federation, Moscow
R. A. Shchegoleva
A. I. Burnazyan Federal Medical Biophisical Center, Federal Medical and Biological Agency of the Moscow
Email: lpsycheva@mail.ru
Russian Federation, Moscow
N. I. Lisina
A. I. Burnazyan Federal Medical Biophisical Center, Federal Medical and Biological Agency of the Moscow
Email: lpsycheva@mail.ru
Russian Federation, Moscow
A. V. Gordeev
A. I. Burnazyan Federal Medical Biophisical Center, Federal Medical and Biological Agency of the Moscow
Email: lpsycheva@mail.ru
Russian Federation, Moscow
L. M. Rozhdestvenskii
A. I. Burnazyan Federal Medical Biophisical Center, Federal Medical and Biological Agency of the Moscow
Email: lpsycheva@mail.ru
Russian Federation, Moscow