Effect of Neuropeptide Y on Action Potential Generation in Working Cardiomyocytes of the Right Atrium in Rat Heart
- Authors: Zverev A.A.1, Anikina T.A.1, Iskakov N.G.1, Zefirov A.L.2, Zefirov T.L.1
-
Affiliations:
- Department of Human Anatomy, Physiology, and Health Protection, Kazan (Volga Region) Federal University
- Department of Normal Physiology, Kazan State Medical University of Ministry of Health of Russia
- Issue: Vol 165, No 5 (2018)
- Pages: 610-612
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/240594
- DOI: https://doi.org/10.1007/s10517-018-4224-5
- ID: 240594
Cite item
Abstract
We studied the effect of neuropeptide Y in concentrations of 10—8-10—6 M on electrical activity of adult rat right atrial cardiomyocytes with preserved spontaneous activity. Neuropeptide Y was found to modulate the amplitude-time parameters of action potential: in concentrations of 10—7 and 10—6 M it reduced the membrane potential, increased the amplitude of action potential and duration of the repolarization phase, and reduced the frequency of action potential generation. In concentration of 10—6 M, neuropeptide Y produced stronger effect on the analyzed parameters, while in concentration of 10—8 M it produced no significant changes.
About the authors
A. A. Zverev
Department of Human Anatomy, Physiology, and Health Protection, Kazan (Volga Region) Federal University
Author for correspondence.
Email: alekcei5@rambler.ru
Russian Federation, Kazan
T. A. Anikina
Department of Human Anatomy, Physiology, and Health Protection, Kazan (Volga Region) Federal University
Email: alekcei5@rambler.ru
Russian Federation, Kazan
N. G. Iskakov
Department of Human Anatomy, Physiology, and Health Protection, Kazan (Volga Region) Federal University
Email: alekcei5@rambler.ru
Russian Federation, Kazan
A. L. Zefirov
Department of Normal Physiology, Kazan State Medical University of Ministry of Health of Russia
Email: alekcei5@rambler.ru
Russian Federation, Kazan, Tatarstan Republic
T. L. Zefirov
Department of Human Anatomy, Physiology, and Health Protection, Kazan (Volga Region) Federal University
Email: alekcei5@rambler.ru
Russian Federation, Kazan