Effect of Neuropeptide Y on Action Potential Generation in Working Cardiomyocytes of the Right Atrium in Rat Heart

Abstract

We studied the effect of neuropeptide Y in concentrations of 10^—8-10^—6 M on electrical activity of adult rat right atrial cardiomyocytes with preserved spontaneous activity. Neuropeptide Y was found to modulate the amplitude-time parameters of action potential: in concentrations of 10^—7 and 10^—6 M it reduced the membrane potential, increased the amplitude of action potential and duration of the repolarization phase, and reduced the frequency of action potential generation. In concentration of 10^—6 M, neuropeptide Y produced stronger effect on the analyzed parameters, while in concentration of 10^—8 M it produced no significant changes.