Effect of α2-Adrenoceptor Stimulation on Functional Parameters of Langendorff-Isolated Rat Heart
- Authors: Ziyatdinova N.I.1, Kuptsova A.M.1, Faskhutdinov L.I.1, Zefirov A.L.2, Zefirov T.L.1
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Affiliations:
- Department of Human Health protection, Kazan (Volga Region) Federal University
- Department of Normal Physiology, Kazan State Medical University, Ministry of Health of the Russian Federation
- Issue: Vol 165, No 5 (2018)
- Pages: 593-596
- Section: Physiology
- URL: https://journals.rcsi.science/0007-4888/article/view/240584
- DOI: https://doi.org/10.1007/s10517-018-4220-9
- ID: 240584
Cite item
Abstract
We studied the effect of α2-adrenoreceptor agonist clonidine hydrochloride in concentrations of 10—9-10—6 M on inotropy, chronotropy, and coronary flow in Langendorff-isolated heart of adult rats. It was found that α2-adrenoreceptor agonist changed all studied parameters. Left ventricular myocardium contraction force decreased after application of all tested concentrations, the maximum effect was observed at a concentration of 10—6 M. Stimulation of α2-adrenergic receptors in concentrations of 10—8, 10—7, and 10—6 M produced a two-phase effect (initial increase and a subsequent decrease) on the coronary flow. Clonidine hydrochloride in the maximum concentration (10—6 M) caused a decrease in HR in one group and an increase in the other.
About the authors
N. I. Ziyatdinova
Department of Human Health protection, Kazan (Volga Region) Federal University
Email: zefirovtl@mail.ru
Russian Federation, Kazan, Republic of Tatarstan
A. M. Kuptsova
Department of Human Health protection, Kazan (Volga Region) Federal University
Email: zefirovtl@mail.ru
Russian Federation, Kazan, Republic of Tatarstan
L. I. Faskhutdinov
Department of Human Health protection, Kazan (Volga Region) Federal University
Email: zefirovtl@mail.ru
Russian Federation, Kazan, Republic of Tatarstan
A. L. Zefirov
Department of Normal Physiology, Kazan State Medical University, Ministry of Health of the Russian Federation
Author for correspondence.
Email: zefirovtl@mail.ru
Russian Federation, Kazan, Republic of Tatarstan
T. L. Zefirov
Department of Human Health protection, Kazan (Volga Region) Federal University
Email: zefirovtl@mail.ru
Russian Federation, Kazan, Republic of Tatarstan