Association of 3111T/C Polymorphism of the Clock Gene with Circadian Rhythm of Melatonin in Menopausal Women with Insomnia
- Authors: Semenova N.V.1, Madaeva I.M.1, Bairova T.A.1, Zhambalova R.M.1, Kalyuzhnaya O.V.1, Rashidova M.A.1, Kolesnikova L.I.1
-
Affiliations:
- Research Center of Family Health and Human Reproduction Problems
- Issue: Vol 165, No 3 (2018)
- Pages: 331-333
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/240272
- DOI: https://doi.org/10.1007/s10517-018-4162-2
- ID: 240272
Cite item
Abstract
We carried out a comparative analysis of circadian rhythms of melatonin secretion in Caucasian menopausal women with and without insomnia depending on the 3111T/C polymorphism of the Clock gene. Melatonin levels was measured in the saliva 4 times a day (06.00-07.00, 12.00-13.00, 18.00-19.00, and 23.00-00.00 h). Carriers of the TT genotype with insomnia demonstrated significantly higher level of melatonin in the early morning hours compared to the carriers of the minor allele C (12.60±7.58 and 8.98±8.62 pg/ml, respectively, p=0.023). In the control group, no statistically significant differences were revealed. The carriers of the TT genotype with sleep disorders have higher morning melatonin level compared to control group women (12.60±7.58 and 5.48±4.74 pg/ml, respectively, p=0.005) and low nocturnal melatonin level (6.42±4.97 and 12.52±10.40 pg/ml, respectively, p=0.039).
About the authors
N. V. Semenova
Research Center of Family Health and Human Reproduction Problems
Author for correspondence.
Email: natkor_84@mail.ru
Russian Federation, Irkutsk
I. M. Madaeva
Research Center of Family Health and Human Reproduction Problems
Email: natkor_84@mail.ru
Russian Federation, Irkutsk
T. A. Bairova
Research Center of Family Health and Human Reproduction Problems
Email: natkor_84@mail.ru
Russian Federation, Irkutsk
R. M. Zhambalova
Research Center of Family Health and Human Reproduction Problems
Email: natkor_84@mail.ru
Russian Federation, Irkutsk
O. V. Kalyuzhnaya
Research Center of Family Health and Human Reproduction Problems
Email: natkor_84@mail.ru
Russian Federation, Irkutsk
M. A. Rashidova
Research Center of Family Health and Human Reproduction Problems
Email: natkor_84@mail.ru
Russian Federation, Irkutsk
L. I. Kolesnikova
Research Center of Family Health and Human Reproduction Problems
Email: natkor_84@mail.ru
Russian Federation, Irkutsk