Transforming Growth Factor-β and Tumor Necrosis Factor-α Reduce the Sensitivity of MiaPaCa2 Pancreatic Cancer Cells to Lysis by NK Cells
- Authors: Ostapchuk E.O.1, Kali A.1, Belyaev N.N.1
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Affiliations:
- Laboratory of Molecular Immunology and Immunobiotechnology, M. A. Aitkhodzhin Institute of Molecular Biology and Biochemistry
- Issue: Vol 165, No 2 (2018)
- Pages: 259-263
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/240211
- DOI: https://doi.org/10.1007/s10517-018-4143-5
- ID: 240211
Cite item
Abstract
We studied the role of cytokines TGF-β and TNFα in reduction of the cytolytic activity of NK cells towards tumor cells. Exogenous TGF-β and TNFα reduced the sensitivity of MiaPaCa2 pancreatic adenocarcinoma cells to NK cytotoxicity, which was associated with reduction of ULBP-1 expression and increase of HLA-E, HLA-G, CD155, and CD112 expression on Mia-PaCa2 cells. Changes in the expression of ligands for NK receptors on tumor cells induced by TGF-β and TNFα may contribute to reduction of cytotoxicity of tumor-associated NK cells and thus prevent an adequate antitumor immune response leading to the disease progress.
About the authors
E. O. Ostapchuk
Laboratory of Molecular Immunology and Immunobiotechnology, M. A. Aitkhodzhin Institute of Molecular Biology and Biochemistry
Author for correspondence.
Email: katyostapchuk@gmail.com
Kazakhstan, Almaty
A. Kali
Laboratory of Molecular Immunology and Immunobiotechnology, M. A. Aitkhodzhin Institute of Molecular Biology and Biochemistry
Email: katyostapchuk@gmail.com
Kazakhstan, Almaty
N. N. Belyaev
Laboratory of Molecular Immunology and Immunobiotechnology, M. A. Aitkhodzhin Institute of Molecular Biology and Biochemistry
Email: katyostapchuk@gmail.com
Kazakhstan, Almaty