Immunochemical Diagnosis of Multiple Myeloma
- Authors: Lyubimova N.V.1, Timofeev Y.S.1, Abaev V.M.1, Votyakova O.M.1, Kushlinskii N.E.1
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Affiliations:
- N. N. Blokhin National Research Medical Center of Oncology, Ministry of Health of the Russian Federation
- Issue: Vol 165, No 1 (2018)
- Pages: 84-87
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/240005
- DOI: https://doi.org/10.1007/s10517-018-4105-y
- ID: 240005
Cite item
Abstract
The diagnostic potentialities of complex immunochemical analysis of the serum and daily urine were evaluated in 118 patients with multiple myeloma. In 95 patients, we observed secretion of monoclonal intact immunoglobulins with heavy chains G (N=69), A (N=19), and M (N=4) and biclonal secretion of paraproteins G and A (N=3). Bence-Jones protein was detected in the sera and daily urine of 16 patients and Bence-Jones proteinuria alone was detected in 3 patients. The diagnostic sensitivity of serum immunoelectrophoresis in multiple myeloma is 94.1%. Analysis of paraproteinuria is particularly important in Bence-Jones myeloma, when paraprotein excretion may be not associated with paraproteinemia. Complex study by immunoelectrophoretic and immunoturbidimetric methods in multiple myeloma increases the diagnostic sensitivity to 99.2%.
About the authors
N. V. Lyubimova
N. N. Blokhin National Research Medical Center of Oncology, Ministry of Health of the Russian Federation
Author for correspondence.
Email: biochimia@yandex.ru
Russian Federation, Moscow
Yu. S. Timofeev
N. N. Blokhin National Research Medical Center of Oncology, Ministry of Health of the Russian Federation
Email: biochimia@yandex.ru
Russian Federation, Moscow
V. M. Abaev
N. N. Blokhin National Research Medical Center of Oncology, Ministry of Health of the Russian Federation
Email: biochimia@yandex.ru
Russian Federation, Moscow
O. M. Votyakova
N. N. Blokhin National Research Medical Center of Oncology, Ministry of Health of the Russian Federation
Email: biochimia@yandex.ru
Russian Federation, Moscow
N. E. Kushlinskii
N. N. Blokhin National Research Medical Center of Oncology, Ministry of Health of the Russian Federation
Email: biochimia@yandex.ru
Russian Federation, Moscow