Antimetastatic Effect of Liposomal Recombinant Lactaptin
- Authors: Kaledin V.I.1, Koval O.A.2,3, Kuligina E.V.2, Lushnikova E.L.4, Nikolin V.P.1, Popova N.A.1,3, Pyshnaya I.A.2, Richter V.A.2
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Affiliations:
- Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
- Institute of Chemical Biology and Fundamental Medicine, Siberian Division of the Russian Academy of Sciences
- Novosibirsk National Research State University
- Institute of Molecular Pathology and Pathomorphology
- Issue: Vol 164, No 6 (2018)
- Pages: 762-765
- Section: Oncology
- URL: https://journals.rcsi.science/0007-4888/article/view/239902
- DOI: https://doi.org/10.1007/s10517-018-4075-0
- ID: 239902
Cite item
Abstract
Antimetastatic effect of the liposomal form of recombinant lactaptin RL2 (a proteolytic fragment of human breast milk κ-casein; 8.6 kDa) was studied in A/Sn mice after intravenous transplantation of GA-1 tumor with high rate of liver metastases. Tumor growth in the liver was found in all mice. In animals dying early, the tumors were presented by multiple nodes of about the same size; in mice dying later, the tumors in the liver were presented by just few large nodes formed by cells that survived chemotherapy. A single intravenous injection of RL2 lactaptin in liposomes prolonged lifespan of animals with liver metastases of GA-1 tumor by 1.5 times in comparison with that in untreated animals.
About the authors
V. I. Kaledin
Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Author for correspondence.
Email: pathol@inbox.ru
Russian Federation, Novosibirsk
O. A. Koval
Institute of Chemical Biology and Fundamental Medicine, Siberian Division of the Russian Academy of Sciences; Novosibirsk National Research State University
Email: pathol@inbox.ru
Russian Federation, Novosibirsk; Novosibirsk
E. V. Kuligina
Institute of Chemical Biology and Fundamental Medicine, Siberian Division of the Russian Academy of Sciences
Email: pathol@inbox.ru
Russian Federation, Novosibirsk
E. L. Lushnikova
Institute of Molecular Pathology and Pathomorphology
Email: pathol@inbox.ru
Russian Federation, Novosibirsk
V. P. Nikolin
Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: pathol@inbox.ru
Russian Federation, Novosibirsk
N. A. Popova
Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences; Novosibirsk National Research State University
Email: pathol@inbox.ru
Russian Federation, Novosibirsk; Novosibirsk
I. A. Pyshnaya
Institute of Chemical Biology and Fundamental Medicine, Siberian Division of the Russian Academy of Sciences
Email: pathol@inbox.ru
Russian Federation, Novosibirsk
V. A. Richter
Institute of Chemical Biology and Fundamental Medicine, Siberian Division of the Russian Academy of Sciences
Email: pathol@inbox.ru
Russian Federation, Novosibirsk